Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

Socially aware persuasive games that use immersive technologies often appeal to empathy, prompting users to feel and understand the struggles of another. However, the often sought-after standing in another's shoes' experience, in which users virtually inhabit another in distress, may complicate other-oriented …

Background: While the participation of adults with visual and severe or profound intellectual disabilities (VSPID) in society and community life is important, evidence-based interventions to improve their participation are lacking. We conducted a process evaluation of the implementation of ‘Care for …

The wine industry in the Czech Republic is a main economic sector, which is verified since the country entered the Europe in 2004. It has a strategic logistic position for exporting to Central and Eastern Europe and has the widest network of hypermarkets and supermarkets in Europe. On another hand, independent …

‘The network is everlasting’ wrote Robert Filliou and George Brecht in 1967, a statement that, at first glance, still seems to be true of today’s world. Yet there are also signs that the omnipresence of networks is evolving into another reality. In recent times, the limits of networks rather than their …

The purpose of this research paper was to answer the central question: How can promotion of electric cars be improved on social media? In order to answer this question desk and field research has been used. First, desk research has been conducted by analysing several articles and marketing books. Multiple …

BACKGROUND: Coach2Move is a personalized treatment strategy by physical therapists to elicit physical activity in community-dwelling older adults with mobility problems. OBJECTIVE: The primary objective of this study is to assess the effectiveness and cost-effectiveness of the implementation of Coach2Move …

Granite G682 is a yellow to pink color stone of the Precambrian period, the most famous yellow granite from China. I am from G682 granite town. I used to live in a village surrounded by stones. however, I never knew the beautiful and scary story behind it until I saw hundreds of abandoned quarries in …

The crossroads of living in cities on the one hand and ageing of the population on the other is studied in an interdisciplinary field of research called urban ageing (van Hoof and Kazak 2018, van Hoof et al. 2018). People live longer and in better health than ever before in Europe. Despite all the positive …

Abstract Background: Many countries in Europe have implemented managed competition and patient choice during the last decade. With the introduction of managed competition, health insurers also became an important stakeholder. They purchase services on behalf of their customers and are allowed to contract …