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Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension

Lemmers, Jacqueline; van Caam, Arjan; Kersten, Brigit E.; van den Ende, Cornelia; Knaapen, Hanneke; van Dijk, Arie; Hagmolen of Ten Have, Wanda; van den Hoogen, Frank; Koenen, Hans J P M; van Leuven, Sander; Alkema, Wynand (Data Science For Life Science & Health); Smeets, Ruben L; Vonk, Madelon C.

Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoantibodies AT1R and ETAR, and several candidate-biomarkers have the …

2023-05-22AlgemeenArtikel

Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Alkema, Wynand (Data Science For Life Science & Health); He, Xuehui; Kaffa, Charlotte; Joosten, Irma; Smeets, Ruben L; Koenen, Hans J P M; Mulder, Michelle L.M.; van den Reek, Juul M.P.A.; Urbano, Paulo C.M.; Wang, Xinhui; van Cranenbroek, Bram; van Rijssen, Esther; Van Den Hoogen, Frank H.J.; de Jong, Elke M. G .J.; Wenink, Mark H.

Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult for dermatologists to implement. We, therefore, aimed …

2021-10-12AlgemeenArtikel

Autoantibody profiles in systemic sclerosis

Alkema, Wynand (Data Science For Life Science & Health); Koenen, Hans J P M; Kersten, Brigit E.; Kaffa, Charlotte; Nannenberg-Koops, Jaqueline W; Damoiseux, Jan G. M. C.

Onderzoek naar de profilering van antilichamen in de prognose en classificatie van systemische sclerose. Het doel van het onderzoek was om commercieel beschikbare diagnostische assays voor de detectie van SSc-geassocieerde autoantilichamen te vergelijken. Daarnaast werder onderzoek gedaan naar de coëxistentie …

2021-04-05AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

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Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension

Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Autoantibody profiles in systemic sclerosis

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

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