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Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS

Buiteman-Kruizinga, Laura A.; van Meenen, David M. P.; Bos, Lieuwe D. J.; van der Heiden, Pim L. J.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Introduction The driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilation that targets the lowest work and force of breathing. Aim To compare transpulmonary …

2023AlgemeenArtikel

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Mechanical insufflation-exsufflation for invasively ventilated critically ill patients

Stilma, Willemke (Faculteit Gezondheid); Verweij, Lotte; Spek, Bea; Scholte Op Reimer, Wilhelmina Johanna Maria; Schultz, Marcus Josephus; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

INTRODUCTION: Mechanical Insufflation-Exsufflation (MI-E) is used as an airway clearance intervention in primary care (home ventilation), long-term care (prolonged rehabilitation after intensive care, neuromuscular diseases, and spinal cord injury), and increasingly in acute care in intensive care units …

2023AlgemeenArtikel

The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults

Swingwood, Ema L; Stilma, Willemke (Faculteit Gezondheid); Tume, Lyvonne N; Cramp, Fiona; Voss, Sarah; Bewley, Jeremy; Ntoumenopoulos, George; Schultz, Marcus J; Scholte Op Reimer, Wilma; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated critically ill adults. Two authors independently …

2022-08-01AlgemeenAndersoortig materiaal

Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study

Roozeman, Jan-Paul; Mazzinari, Guido; Serpa Neto, Ary; Hollmann, Markus W.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.; Pisani, Luigi

BACKGROUND: The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID-19. METHODS: This was a post-hoc analysis of a national multicenter cohort study in invasively …

2022-04AlgemeenArtikel

Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients-Insights from the PRoVENT-COVID Observational Study

Stilma, Willemke (Faculteit Gezondheid); van Meenen, David M. P.; Valk, Christel M. A.; de Bruin, Hendrik; Paulus, Frederique (Centre Of Expertise Urban Vitality); Serpa Neto, Ary; Schultz, Marcus J.

We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) in a national, multicenter observational study, …

2021-10AlgemeenArtikel

Mortality associated with early changes in ARDS severity in COVID-19 patients - Insights from the PRoVENT-COVID study

Schuijt, Michiel T.U.; Martin-Loeches, Ignacio; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Neto, Ary Serpa; Stilma, W. (Faculteit Gezondheid)

PURPOSE: We investigated changes in ARDS severity and associations with outcome in COVID-19 ARDS patients. METHODS: We compared outcomes in patients with ARDS classified as 'mild', 'moderate' or 'severe' at calendar day 1, and after reclassification at calendar day 2. The primary endpoint was 28-day …

2021-10AlgemeenArtikel

Airway Care Interventions for Invasively Ventilated Critically Ill Adults-A Dutch National Survey

Stilma, Willemke (Faculteit Gezondheid); van der Hoeven, Sophia M.; Scholte op Reimer, Wilma J. M.; Schultz, Marcus J.; Rose, Louise; Paulus, Frederique (Centre Of Expertise Urban Vitality)

Airway care interventions may prevent accumulation of airway secretions and promote their evacuation, but evidence is scarce. Interventions include heated humidification, nebulization of mucolytics and/or bronchodilators, manual hyperinflation and use of mechanical insufflation-exsufflation (MI-E). Our …

2021-08AlgemeenArtikel

Practice of adjunctive treatments in critically ill COVID-19 patients-rational for the multicenter observational PRoAcT-COVID study in The Netherlands

Valk, Christel M. A.; Swart, Pien; Boers, Leonoor S.; Botta, Michela; Bos, Lieuwe D. J,; de Abreu, Marcelo Gama; Hol, Liselotte; Hollmann, Markus W.; Horn, Janneke; Martin-Loeches, Ignacio; Mazzinari, Guido; Myatra, Sheila N.; Nijbroek, Sunny G.; Rosenberg, Neeltje M.; Stilma, Willemke (Faculteit Gezondheid); Tsonas, Anissa M.; van der Ven, Ward H.; Neto, Ary Serpa; Schultz, Marcus J.; Paulus, Frederique

Background: Patients with coronavirus disease 2019 (COVID-19) may need hospitalization for supplemental oxygen, and some need intensive care unit (ICU) admission for escalation of care. Practice of adjunctive and supportive treatments remain uncertain and may vary widely between countries, within countries …

2021-05AlgemeenArtikel

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