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Supporting resilience of older adults with cognitive decline requires a multi-level system approach

Peeters, G.; Kok, A.A.L.; Bruin S. de (Lector); Bakker, F.C. (Associate Lector)

The concept of resilience, i.e., the capacity of a system to bounce back after a stressor, is gaining interest across many fields of science, policy and practice. To date, resilience research in people with cognitive decline has predominantly addressed the early stages of decline. We propose that: (1) …

2023-02-08Mens & Maatschappij; …Artikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients

Koevoets, E.W.; Geerlings, M.I.; Monninkhof, E.M.; Mandl, R.; Witlox, L.; van der Wall, E.; Stuiver, M.M. (Lectoraat Functioneel Herstel Bij Kanker); Sonke, G.S.; Velthuis, M.J.; Jobsen, J.J.; van der Palen, J.; Bos, M.E.M.M.; Göker, E.; Menke-Pluijmers, M.B.E.; Sommeijer, D.W.; May, A.M.; de Ruiter, M.B.; Schagen, S.B.

Background Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical …

2023AlgemeenArtikel

Dementia in People with Severe/Profound Intellectual (and Multiple) Disabilities:

Wissing, Maureen; Dijkstra, Roos; van der Wal, Ina A.; Grootendorst, Esther S.; Hobbelen, Johannes (Ageing And Allied Health Care); van der Putten, Annette A. J.; De Deyn, Peter Paul; Waninge, Aly (Participation And Health Of Persons With Intellectual And Visual Disabilities); Dekker, Alain D.

Introduction: Diagnosing dementia in people with severe/profound intellectual (and multiple) disabilities (SPI(M)D) is complex. Whereas existing dementia screening instruments as a whole are unsuitable for this population, a number of individual items may apply. Therefore, this study aimed to identify …

2022-08-29AlgemeenArtikel

Dementia in People with Severe/Profound Intellectual (and Multiple) Disabilities:

Wissing, Maureen; Fokkens, Andrea; Dijkstra, Roos; Hobbelen, Johannes (Ageing And Allied Health Care); van der Putten, A. A. J.; De Deyn, Peter Paul; Waninge, Aly (Participation And Health Of Persons With Intellectual And Visual Disabilities); Dekker, Alain D.

Introduction Observable dementia symptoms are hardly studied in people with severe/profound intellectual (and multiple) disabilities (SPI(M)D). Insight in symptomatology is needed for timely signaling/diagnosis. This study aimed to identify practice-based observations of dementia symptoms in this population. …

2022-04-22AlgemeenArtikel

Frailty among Older People during the First Wave of the COVID-19 Pandemic in The Netherlands

Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); van der Lucht, Fons (Healthy Ageing, Allied Health Care And Nursing); van Munster, Barbara C; Krijnen, Wim P (Healthy Ageing, Allied Health Care And Nursing); Hobbelen, Hans (Healthy Ageing, Allied Health Care And Nursing); Finnema, Evelyn J; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Barf, Hans

Restrictive measures due to the COVID-19 pandemic may cause problems in the physical, social, and psychological functioning of older people, resulting in increased frailty. In this cross-sectional study, we aimed to assess the prevalence and characteristics of frailty, to examine differences in perceived …

2022-03-19AlgemeenArtikel

Implementation of a lifestyle intervention for people with a severe mental illness (SMILE)

Florine Walburg (Lid Lectoraat); Johanna W de Joode; Hella E. Brandt; M.W van Tulder; M.C Adriaanse; B.K.G. (Berno) van Meijel (Lector)

Abstract Background: Several interventions have been developed to improve physical health and lifestyle behaviour of people with a severe mental illness (SMI). Recently, we conducted a pragmatic cluster-randomised controlled trial which evaluated the efects of the one-year Severe Mental Illness Lifestyle …

2022-02-05GezondheidArtikel

Development of a personalized substance use disorder treatment for people with mild intellectual disabilities or borderline intellectual functioning

Gosens, Lotte C.F.; Otten, Roy; de Jonge, Jannet M. (Lectoraat Geïntegreerde Complexe Zorg); Schellekens, Arnt F.A.; VanDerNagel, Joanneke E.L.; Didden, Robert; Poelen, Evelien A.P

Background: The prevalence of Substance Use Disorder (SUD) in people with Mild Intellectual Disability and Borderline Intellectual Functioning (MID-BIF) is high and evidence-based treatment programs are scarce. The present study describes the development of a personalised SUD treatment for people with …

2022AlgemeenArtikel

Dementia in people with severe or profound intellectual (and multiple) disabilities

Dekker, Alain D; Wissing, Maureen B G; Ulgiati, Aurora M; Bijl, Bas; van Gool, Gaby; Groen, Marieke R; Grootendorst, Esther S; van der Wal, Ina A; Hobbelen, Johannes S M (Ageing And Allied Health Care); De Deyn, Peter P; Waninge, Aly (Healthy Ageing, Allied Health Care And Nursing)

BACKGROUND: Differentiating dementia from baseline level of functioning is difficult among people with severe/profound intellectual (and multiple) disabilities. Moreover, studies on observable dementia symptoms are scarce. This study examined (a) the relevance of dementia diagnosis, (b) observable symptoms …

2021-11AlgemeenArtikel

Clinimetrics

Emmylou Beekman (Lector); Sandra Lüttmann

Description: The Neck Pain and Disability Scale (NPDS or NPAD) is a questionnaire aiming to quantify neck pain and disability.1 It is a patient-reported outcome measure for patients with any type of neck pain, of any duration, with or without injury.1,2 It consists of 20 items: three related to pain …

2021-10-01GezondheidArtikel

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