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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Ortí-Casañ, N.; Boerema, A.S. (Lid Lectoraat); Köpke, K.; Ebskamp, A.; Keijser, J.; Zhang, Y.; Chen, T.; Dolga, A.M.; Broersen, K.; Fischer, R.; Pfizenmaier, K.; Kontermann, R.E.; Eisel, U.L.M.

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

2023-06-30GezondheidArtikel

A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: a proof of concept

Karin Gehring (Onderzoeker); Martijn M. Stuiver (Onderzoeker); Eva Visser (Onderzoeker); Corelien Kloek (Onderzoeker); Martin van den Bent (Onderzoeker); Monique Hanse (Onderzoeker); Cees Tijssen (Onderzoeker); Geert-Jan Rutten (Onderzoeker); Martin J.B. Taphoorn (Onderzoeker); N.K. Aaronson (Onderzoeker); Margriet Sitskoorn (Onderzoeker)

Abstract Background: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed …

2020GezondheidArtikel

A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma

Gehring, Karin; Stuiver, Martijn M; Visser, Eva; Kloek, Corelien; van den Bent, Martin; Hanse, Monique; Tijssen, Cees; Rutten, Geert-Jan; Taphoorn, Martin J B; Aaronson, Neil K; Sitskoorn, Margriet M

BACKGROUND: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to …

2019-11-21AlgemeenArtikel

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

Liberman, Keliane; Njemini, Rose; Luiking, Yvette; Forti, Louis N.; Verlaan, Sjors; Bauer, Jürgen M.; Memelink, Robert; Brandt, Kirsten; Donini, Lorenzo; Maggio, Marcello; Mets, Tony; Weijers, Sander L.J.; Sieber, Cornel; Cederholm, Tommy; Bautmans, Ivan

Background: A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation …

2019-06AlgemeenArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: a proof of concept

A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

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