HBO Kennisbank

Probleemstelling: NAFLD/NASH is een aandoening welk samen gaat met aanwezigheid van diabetes mellitus (DMII),verhoogd alat-waarde, hyperlipidemie en cardiovasculaire aandoeningen. De fibroscan® is een gevalideerd instrument welk de mate van leverfibrose vaststelt. Aantal NASH/NAFLD patiënten in tweedelijnszorg …

2017-09-01GezondheidMaster

PhytoSana @ ILST

Faber, Folkert

Voortgangspresentatie PhytoSana-project. Bijdrage Hanzehogeschool, Instituut voor Life Science & Technology.

2014-08-27GezondheidConferentiebijdrage

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand (Data Science For Life Science & Health)

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand (Data Science For Life Science & Health)

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

Hydroximic acid derivatives

Crul, Tim; Toth, Noemi; Piotto, Stefano; Literati-Nagy, Peter; Tory, Kalman; Haldimann, Pierre; Kalmar, Bernadett; Greensmith, Linda; Torok, Zsolt; Balogh, Gabor; Gombos, Imre; Campana, Federica; Concilio, Simona; Gallyas, Ferenc; Nagy, Gabor; Berente, Zoltan; Gungor, Burcin; Peter, Maria; Glatz, Attila; Hunya, Akos; Literati-Nagy, Zsuzsanna; Vigh, Laszlo; Hoogstra-Berends, Femke; Heeres, André (Biobased Ingredients And Materials); Kuipers, Irma; Loen, Lizette; Seerden, Jean-Paul; Zhang, Deli; Meijering, Roelien A M; Henning, Robert H; Brundel, Bianca J J M; Kampinga, Harm H; Koranyi, Laszlo; Szilvassy, Zoltan; Mandl, Jozsef; Sumegi, Balazs; Febbraio, Mark A; Horvath, Ibolya; Hooper, Philip L; Vigh, Laszlo

According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

2013AlgemeenArtikel

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