Hereditary Breast and Ovarian Cancer (HBOC) typically arises from mutations inherited in the germline. BRCA1 and BRCA2 mutaions are predominant contributors to HBOC, accounting for the majority of cases. These mutations are associated with 10% of ovarian cancer cases and 3-5% of breast cancer cases [4]. BRCA1 …

Drought, caused by climate change, poses a significant threat to the production of barley. To ensure high yields, drought adaptation in barley is critical. Roots are primarily responsible for water uptake, and during drought, when water levels are low, deep rooting traits are crucial for developing drought-tolerant …

Arrhythmogenic Cardiomyopathy (ACM), also known as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare hereditary disease of the heart, where the connective, and fatty tissue is deposited in the muscle tissue of the ventricular myocardium primarily of the right but also left …

Automation of transport has several potential advantages, such as an increase in road capacity, in road safety and in driving comfort. In addition, automation offers a significant solution to the growing challenge of the driver shortage. In this report, we examine the impact of using autonomous vehicles …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Purpose This study aims to qualitatively examine the relationship between the indoor environmental quality (IEQ), lecturers’ and students’ perceived internal responses and academic performance. Design/methodology/approach To capture user experiences with the IEQ in classrooms, semi-structured interviews …

Tropical peatlands cover around 45 million hectares of the world. Half of these peatlands are located in Indonesia, mostly on Kalimantan. Tropical peatlands are currently under threat due to land-use change, drainage and climate change. One of these locations under threat is Desa Gohong (Gohong village), …

Cardiovascular diseases (CVDs) are by far the leading cause of death due to non communicable diseases in the world. The development of CVDs in many cases is caused by atherosclerosis. In atherosclerosis, plaques in blood vessels are formed by the excessive accumulation of lipids in the endothelial lining. …

Due to the Covid-19 crisis, higher education was forced to offer online alternatives to their courses. This change drastically increased the number of students partaking in online education. However, the effects of obligatory online education could potentially be harmful and are not yet sufficiently …