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Early Signs of Impaired Gut Function Affect Daily Functioning in Patients With Advanced Cancer Undergoing Chemotherapy

Barbara van der Meij; N.E.P. Deutz; RE Rodriguez; Marscha Engelen

Background Gastrointestinal symptoms are common during chemotherapy, but underlying disturbances in gut function and their impact on daily life are unclear. This study investigates gut function in a heterogenous group of cancer patients with gastrointestinal symptoms during chemotherapy and its relation …

2021AlgemeenArtikel

The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patients with cancer: A systematic review and meta-analysis

CN Lam; AE Watt; EA Isenring; Marian de van der Schueren; Barbara van der Meij

Background & aims: Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been proposed as a potential therapy for cancer-related malnutrition, which affects up to 70% of patients with cancer. The aim of this systematic review and meta-analysis was to examine the effects of oral omega-3 PUFA supplementation …

2021AlgemeenArtikel

State of the art: the role of citrulline as biomarker in patients with chemotherapy- or graft-versus-host-disease-induced mucositis

I.M. Dekker; H Bruggink; Barbara van der Meij; N. Wierdsma

Purpose of review Serum or plasma citrulline levels are used as biomarker for a broad spectrum of intestinal functions. During high-dose chemotherapy, citrulline levels are decreased due to mucositis, a common side effect of chemotherapy. This may decrease intestinal function and result in diarrhea. …

2021AlgemeenArtikel

Health-related quality of life and treatment effects in patients with well-differentiated gastroenteropancreatic neuroendocrine neoplasms

Ronde, Elsa M.; Heidsma, Charlotte M.; Eskes, Anne M. (Faculteit Gezondheid); Schopman, Josefine E.; Nieveen van Dijkum, Elisabeth J.M.

Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are often diagnosed in an advanced stage. As the optimal sequence of therapy remains largely unclear, all treatment-related outcomes, including health-related quality of life (HRQoL) prospects, should be assessed according to patients' …

2021AlgemeenAndersoortig materiaal

Continuous versus intermittent infusion of cefotaxime in critically ill patients

Aardema, Heleen; Bult, Wouter; van Hateren, Kai; Dieperink, Willem; Touw, Daan J; Alffenaar, Jan-Willem C; Zijlstra, Jan G; Dieperink, Willem

BACKGROUND: In critical care patients, reaching optimal β-lactam concentrations poses challenges, as infections are caused more often by microorganisms associated with higher MICs, and critically ill patients typically have an unpredictable pharmacokinetic/pharmacodynamic profile. Conventional intermittent …

2020-02-01AlgemeenArtikel

Low muscle mass is associated with early termination of chemotherapy related to toxicity in patients with head and neck cancer

Sealy, Martine J. (Healthy Ageing, Allied Health Care And Nursing); Dechaphunkul, Tanadech; van der Schans, Cees P. (Healthy Ageing, Allied Health Care And Nursing); Krijnen, Wim P (Statistical Techniques For Applied Research); Roodenburg, Jan L. N.; Walker, John; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Baracos, Vickie E.

BACKGROUND & AIMS: We studied whether low pre-treatment muscle mass, measured with CT at thoracic (T4) or lumbar level (L3) associates with early termination of chemotherapy related to toxicity in head and neck cancer (HNC) patients. METHODS: This was a retrospective chart and image review. Adult HNC …

2020-02AlgemeenArtikel

The effect of nutritional counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy: A randomized controlled trial

A. van der Werf; J.A.E. Langius; A Beeker; AJ ten Tije; AJ Vulink; A Haringhuizen; J Berkhof; HJ van der Vliet; H.M.W. Verheul; Marian de van der Schueren

Background & aims: A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of nutritional counseling on change in muscle mass and treatment outcome in patients with …

2020AlgemeenArtikel

Adherence to and satisfaction with low-intensity physical activity and supervised moderate-high intensity exercise during chemotherapy for breast cancer

van Waart, Hanna; Buffart, Laurien M.; Stuiver, Martijn M.; van Harten, Wim H.; Sonke, Gabe S.; Aaronson, Neil K.

PURPOSE: In this study, we investigated factors associated with program adherence and patient satisfaction with a home-based physical activity program (Onco-Move, N = 77) and a supervised exercise program with a home-based component (OnTrack, N = 76). METHODS: We assessed adherence via self-report (home-based …

2020AlgemeenArtikel

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Karsten, Rebecca T.; van der Molen, Lisette; Hamming-Vrieze, Olga; van Son, RobJ. J. J. H.; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.; Stuiver, Martijn M (Centre Of Expertise Urban Vitality); Smeele, Ludi E.

BACKGROUND: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). METHODS: Subjective and objective swallowing, trismus, and …

2020AlgemeenArtikel

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

Witlox, Lenja; Schagen, Sanne B; de Ruiter, Michiel B; Geerlings, Mirjam I; Peeters, Petra H M; Koevoets, Emmie W; van der Wall, Elsken; Stuiver, Martijn (Faculteit Gezondheid); Sonke, Gabe; Velthuis, Miranda J; Palen, Job A M van der; Jobsen, Jan J; May, Anne M; Monninkhof, E M

INTRODUCTION: After treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive effects in healthy older adults and people with mild cognitive impairment. The …

2019-06AlgemeenArtikel

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