5% to 10% of all cancers are linked to gene mutations inherited from parents. The most common gene related to hereditary cancer is the p53 gene. It is a crucial tumor suppressor. However, the mutated gene is commonly inherited from one generation to another one. The functions of p53 resume to the activation …

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …

Introduction: The notion of autonomy in Self-Determination Theory is at the core of intrinsically motivated learning, and fulfilment of the need for autonomy is essential for thriving at school. Therefore teacher-provided autonomy support has grown into a key concern in educational research. In the present …

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

This study reports on strategies to indicate plural referents in hearing learners of Sign Language of the Netherlands. This is the first explorative study that focuses on L2 expressions of plurality in a sign language. Using data from two datasets, I examined when learners start to express plural and …

AI tools increasingly shape how we discover, make and experience music. While these tools can have the potential to empower creativity, they may fundamentally redefine relationships between stakeholders, to the benefit of some and the detriment of others. In this position paper, we argue that these tools …

Background The challenging combination of breastfeeding and work is one of the main reasons for early breastfeeding cessation. Although the availability of a lactation room (defined as a private space designated for milk expression or breastfeeding) is important in enabling the combination of breastfeeding …

Research has shown that breastfeeding has important long-term health effects on both children and mothers. The World Health Organization therefore recommends that children be exclusively breastfed for the first six months of life and that breastfeeding be continued thereafter, alongside complementary …

Non-small cell lung cancer (NSCLC) occurs in approximately 80-85% of all lung cancer patients and has a 5-year overall survival (OS) of only 15-20%. In this study, 29 NSCLC patients received neoadjuvant treatment with Chemoradiotherapy, Nivolumab, and Ipilimumab. This study aimed to investigate the effects …