Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle …

BACKGROUND: Existing research shows that a high consumption of animal products contributes to climate change. To not further exhaust natural resources, a diet containing more plant-based foods is necessary. The problem with plant-based foods is their protein quality. This review aims to study of the …

Doel: Het onderzoeken van mogelijke associaties tussen de maternale voedingsinname (energie, eiwit, koolhydraten, vet en verzadigd vet) van vrouwen met hyperemesis gravidarum en de cardio-metabole markers in het navelstrengbloed van de nakomeling. Achtergrond: Hyperemesis gravidarum (HG) treft zo’n 0,2-3,6% …

Background Gastrointestinal symptoms are common during chemotherapy, but underlying disturbances in gut function and their impact on daily life are unclear. This study investigates gut function in a heterogenous group of cancer patients with gastrointestinal symptoms during chemotherapy and its relation …

(1) Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving …

The metabolic syndrome (MetS) comprises cardiometabolic risk factors frequently found in individuals with obesity. Guidelines to prevent or reverse MetS suggest limiting fat intake, however, lowering carbohydrate intake has gained attention too. The aim for this review was to determine to what extent …

PURPOSE: To assess the association of clinical variables and the development of specified chronic conditions in ICU survivors. MATERIALS AND METHODS: A retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data from 2012 to …

Patients who had an ischemic stroke have a poor life expectancy. To improve prognosis in ischemic stroke it is needed to discover additional prognostic biomarkers. This study investigated whether sarcopenia or myosteatosis affected long-term survival in ischemic stroke patients. The secondary aim was …

Background: Diabetes mellitus is considered the fifth in the top five causes of noncommunicable disease related deaths in the world. Treatment ranges from lifestyle changes to medication. Intermittent fasting (IF) shows glucose lowering results in rats and might be a possibility for human therapy. Objectives: …