Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …

Local online retail platforms (LORPs) are gaining popularity as digital channels that can increase physical retail agglomerations’ attractiveness and viability by stimulating online sales and consumer footfall. However, insights are needed to enrich academic understanding and guide practitioners in their …

Anthropogenic changes to estuaries, usually highly productive systems, may result in increased turbidity levels, suppress pelagic primary production and negatively affect ecosystem functions. The Ems-Dollard estuary, enclosed between the Netherlands and Germany, is such an estuary with a long history …

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

Floating photovoltaics (FPV) is emerging as a promising renewable energy technology which enables the production of electricity on surface waters. While this technology could potentially make an important contribution to the energy transition, the current uncertainty about the water quality effects of …

Food insecurity remains a critical challenge, especially for developing countries like Kenya. While factors such as high poverty rate, rural-urban migration, pandemics including Covid-19, desert locusts, etcetera remain part of immediate causes, shocks resulting from climate change, such as drought, …

The dynamic inflow effect describes the unsteady aerodynamic response to fast changes in rotor loading due to the inertia of the wake. Fast changes in turbine loading due to pitch actuation or rotor speed transients lead to load overshoots. The phenomenon is suspected to be also relevant for gust situations; …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

The EU Maritime Spatial Planning Directive (MSPD) requires the member states (MS) to pursue Blue Growth while ensuring good environmental status (GES) of sea areas. An ecosystem-based approach (EBA) should be used for the integration of the aims. However, the MSPD does not specify how the MS should arrange …