HBO Kennisbank

25 Resultaten

Sorteer op:

Taste alterations during treatment with protein kinase inhibitors: a pilot study.

A. van der Werf; Marian de van der Schueren; M. Rovithi; M. Labots; S.M.S. Hashemi; J.A.E. Langius; H.M.W. Verheul

2018AlgemeenArtikel

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer

Anja Thronicke (Onderzoeker); Megan L. Steele (Onderzoeker); Christian Grah (Onderzoeker); Burkhard Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and …

2017-12-13GezondheidArtikel

Synthesis of C-1 Fluorinated Methyl Deoxythymidine-α-diphosphate-β-L-rhamnose Analogues as Inhibitors of Nucleotidylyl- and Rhamnosyltransferases.

Sherany Winter (Student)

Het is bekend dat bacteriën resistent worden tegen recent gebruikte antibiotica, dit resulteert in een vraag naar nieuwe medicijnen. Rhamnose is een 6-deoxy-L-suiker en vormt een belangrijk onderdeel van de bacteriële celwand. De biosynthese van deze suiker vindt alleen op natuurlijke wijze in bacteriën …

2016-11-25TechniekBachelor

Association of proton pump inhibitor use with recurrent falls and risk of fractures in older women: a study of medication use in older fallers

H.W. Thaler; C.S. Sterke; T.J.M. van der Cammen

Objectives To examine the association between Proton pump inhibitors (PPIs) use and falls and fractures. Design A cross-sectional study. Setting and participants 400 female patients aged 70 years or older who were consecutively admitted to the Trauma Center Meidling, Vienna, after a fall and who required …

2016-01-08GezondheidArtikel

Stop or Go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

H. Burger; N.M. Molenaar; H.W. Torij (Lector); G.J. Bonsel; M.P. Lambregtse - van den Berg; W.J.G. Hoogendijk; M.E. Brouwer; C.L.H. Bockting; J.J. Duvekot; C.N. van der Veere

Approximately 6.2% of women in the USA and 3.7% of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2%. Nonetheless, SSRI use during pregnancy is still controversial. On the …

2016-01-01GezondheidArtikel

De maagwand uptake van patiënten die Proton Pump Inhibitors gebruiken bij een myocardperfusiescan.

Inge Gerritsen (Student); Marjon Gevers (Begeleider)

leiding: Door toediening van een radiofarmacon, zoals Technetium-99m-Sestamibi (99mTc-Sestamibi), kan met een myocardperfusiescan de doorbloeding van het hart in beeld gebracht worden. Dit radiofarmacon wordt opgenomen door de hartspier, maar kan ook opgenomen worden door de maagwand. Uptake in de maagwand …

2016GezondheidBachelor

Hydroximic acid derivatives

Crul, Tim; Toth, Noemi; Piotto, Stefano; Literati-Nagy, Peter; Tory, Kalman; Haldimann, Pierre; Kalmar, Bernadett; Greensmith, Linda; Torok, Zsolt; Balogh, Gabor; Gombos, Imre; Campana, Federica; Concilio, Simona; Gallyas, Ferenc; Nagy, Gabor; Berente, Zoltan; Gungor, Burcin; Peter, Maria; Glatz, Attila; Hunya, Akos; Literati-Nagy, Zsuzsanna; Vigh, Laszlo; Hoogstra-Berends, Femke; Heeres, André (Biobased Ingredients And Materials); Kuipers, Irma; Loen, Lizette; Seerden, Jean-Paul; Zhang, Deli; Meijering, Roelien A M; Henning, Robert H; Brundel, Bianca J J M; Kampinga, Harm H; Koranyi, Laszlo; Szilvassy, Zoltan; Mandl, Jozsef; Sumegi, Balazs; Febbraio, Mark A; Horvath, Ibolya; Hooper, Philip L; Vigh, Laszlo

According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

2013AlgemeenArtikel

Dose–response relationship between selective serotonin re‐uptake inhibitors and injurious falls: a study in nursing home residents with dementia

C.S. Sterke; G. Ziere; C.W.N. Looman; T.J.M. van der Cammen

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Patients treated with selective serotonin re‐uptake inhibitors (SSRIs) have been shown to have an increased risk of falling. In nursing homes, many patients with dementia are given SSRIs as a treatment for depression. In this group, however, the possible risk …

2012-04-05GezondheidArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

A study of balance, gait and psychotropic drug use in relation to fall risk in nursing home residents with dementia

C.S. Sterke

Falls are a major health problem in nursing home residents with dementia. In nursing homes one-third of all falls results in an injury. In order to take tailor-made preventive measures in time, the fall risk profile of each individual nursing home resident should be periodically evaluated. A systematic …

2011-11-25GezondheidBoek

1 2 3

Over HBO Kennisbank