In dit praktijkgericht onderzoek wordt onderzocht in hoeverre non-coplanaire VMAT SRS als aanvulling op coplanaire VMAT SRS de treatment planning kwaliteit in de behandeling van enkelvoudige hersenmetastasen verbetert en of deze verbetering opweegt tegen een door rotaties van de bestralingstafel veroorzaakte …

The objective of this study was to introduce a new iterative method to reconstruct multi leaf collimator (MLC) positions based on low resolution ionization detector array measurements and to evaluate its error detection performance. The iterative reconstruction method consists of a fluence model, a detector …

OBJECTIVES: To demonstrate that novice dosimetry planners efficiently create clinically acceptable IMRT plans for head and neck cancer (HNC) patients using a commercially available multicriteria optimization (MCO) system. METHODS: Twenty HNC patients were enrolled in this in-silico comparative planning …

Background: Computed tomography (CT) is one of the most used modalities for diagnostics in paediatric populations, which is a concern as it also delivers a high patient dose. Research has focused on developing computer algorithms that provide better image quality at lower dose. The iterative reconstruction …

Background and purpose: Treatment plan verification of intensity modulated radiotherapy (IMRT) is generally performed with the gamma index (GI) evaluation method, which is difficult to extrapolate to clinical implications. Incorporating Dose Volume Histogram (DVH) information can compensate for this. …

When treating cancer by radiation therapy it is always the goal to irradiate the tumour as much as possible and to spare the healthy tissue around it. For this a new type of radiation therapy called Volumetric Modulated ARC Therapy (VMAT) has been developed. During VMAT treatment the radiation machine …

Het is moeilijk om eenduidig vast te stellen welke behandelingsmethode, Intensity Modulated Radiotherapy (IMRT) of High Dose Rate (HDR) brachytherapie, de voorkeur heeft bij focal therapy van patiënten met een prostaatcarcinoom. Het is nog onduidelijk wat de invloed van het prostaatvolume en de locatie …

PURPOSE: Advanced radiotherapy treatments require appropriate quality assurance (QA) to verify 3D dose distributions. Moreover, increase in patient numbers demand efficient QA-methods. In this study, a time efficient method that combines model-based QA and measurement-based QA was developed; i.e., the …

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

The COMPASS system (IBADosimetry) is a quality assurance (QA) tool which reconstructs 3D doses inside a phantom or a patient CT. The dose is predicted according to the RT plan with a correction derived from 2D measurements of a matrix detector. This correction method is necessary since a direct reconstruction …