The architecture of TP 53 , the most frequently mutated gene in human cancer, is more complex than previously thought. Using TP 53 variants as clinical biomarkers to predict response to treatment or patient outcome requires an unequivocal and standardized procedure toward a definitive strategy for the …

In opdracht van ING Alphen aan den Rijn is een onderzoek naar de klanttevredenheid uitgevoerd. ING is een wereldwijde financiële instelling die diensten levert op het gebied van bankieren en verzekeren. ING is betrokken bij haar klanten. Zij dienen het klantbelang centraal te stellen in hun handelen. …

This thesis intends to find out how CityFilm can export its concept successfully in order to enter a new market. CityFilm is a small Dutch media marketing company that successfully creates promotional destination videos of cities, presenting them worldwide to the wealthy customer through professional …

Background: While the interest of health promotion researchers in change methods directed at the target population has a long tradition, interest in change methods directed at the environment is still developing. In this survey, the focus is on methods for environmental change; especially about how these …

As a practitioner, a manager and a scientist in social work for 40 years, I am still intrigued by the social work positioning and legitimating processes. Its recognition by users and financiers is often diffuse and its fragmentation sometimes hinders effective interventions. In social work itself, …

Mammalian promoters can be separated into two classes, conserved TATA box-enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We have sequenced tags corresponding to several hundred thousand transcription start sites (TSSs) in the mouse …