Background: A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation …

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental …

Accumulating evidence dismisses the idea that bacteria are solitary bugs, living a completely independent existence. Instead, this definition is being replaced by the notion that bacteria are intimately communicating organisms holding tight relations to one another. One such process through which this …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Probleemstelling: Oestrogeenpreparaten die door postmenopauzale vrouwen gebruikt worden om de verschijnselen van de postmenopauze te onderdrukken, kunnen een verhoogde kans op trombose en borstkanker geven, maar over de uitwerking van deze medicijnen op de huid wordt nauwelijks gesproken. Gezien de vergrijzing, …

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

Deze scriptie bespreekt de rol van Sialoadhesin op macrofagen in het Guillain-Barré syndroom geinduceerd door Campylobacter jejuni. Sialoadhesin is een receptor gevonden op macrofagen welke mogelijk een rol speelt in de ontwikkeling van Guillain-Barré. Een neuromusculaire ziekte, waarbij verlamming van …

The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives …