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How do dislocation rates differ between different approaches to total hip arthroplasty? A systematic review and meta-analysis

Koster, Marc; Luzier, Anton D.; Temmerman, Olivier P.P.; Vos, Stan J.; Benner, Joyce L.

Background: Different surgical approaches for total hip arthroplasty (THA) exist, without predisposition when it comes to dislocation risk. The direct anterior approach (DAA) is thought to have reduced risk since soft tissue trauma is minimalized. Therefore, we assessed the dislocation risk for different …

2023-06AlgemeenArtikel

A proteomics approach to identify COPD-related changes in lung fibroblasts

Bekker, Nicolaas J.; van Pijkeren, Alienke; Wolters, Justina C.; Sánchez Brotons, Alejandro; Guryev, Victor; Woldhuis, Roy R.; Bischoff, Rainer; Alkema, Wynand (Data Science For Life Science & Health); Horvatovich, Peter; van Nijnatten, Johannes L.L.; van den Berge, Maarten; Timens, Wim; Brandsma, Corry-Anke

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

2023-04-01AlgemeenArtikel

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

van der Hoek, Sjoukje; Willemsen, Antoon T.M.; Visser, Ton; Heeres, Andre (Biobased Chemistry & Refinery); Mulder, Douwe J.; Bokkers, Reinoud P.H.; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J.L.; Stevens, Jasper

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

2023-03-10AlgemeenArtikel

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy

Akdemir, Emine; Sweegers, Maike G; Vrieling, Alina; Rundqvist, Helene; Meijer, Richard P; Leliveld-Kors, Annemarie M; van der Heijden, Antoine G; Rutten, Vera C; Koldewijn, Evert L; Bos, Siebe D; Wijburg, Carl J; Marcelissen, Tom A T; Bongers, Bart C; Retèl, Valesca P; van Harten, Wim H; May, Anne M; Groen, Wim G; Stuiver, Martijn M (Lectoraat Functioneel Herstel Bij Kanker)

Introduction Radical cystectomy (RC) is the standard treatment for patients with non-metastatic muscle-invasive bladder cancer, as well as for patients with therapy refractory high-risk non-muscle invasive bladder cancer. However, 50–65% of patients undergoing RC experience perioperative complications. …

2023-03AlgemeenArtikel

Physical activity and physical fitness in children with heritable connective tissue disorders

de Koning, Lisanne (Centre Of Expertise Urban Vitality); Warnink-Kavelaars, Jessica; van Rossum, Marion; Limmen, Selina; Van der Looven, Ruth; Muiño-Mosquera, Laura; van der Hulst, Annelies; Oosterlaan, Jaap; Rombaut, Lies; Engelbert, Raoul (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten)

Objectives: Health problems in patients with heritable connective tissue disorders (HCTD) are diverse and complex and might lead to lower physical activity (PA) and physical fitness (PF). This study aimed to investigate the PA and PF of children with heritable connective tissue disorders (HCTD). Methods: …

2023AlgemeenArtikel

Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA

Thudium, Christian S.; Engstrøm, Amalie; Bay-Jensen, Anne Christine; Frederiksen, Peder; Jansen, Nuria; De Zwart, Arjan; van der Leeden, Marike; Dekker, Joost; Lems, Willem; Roorda, Leo; van Spil, Willem Evert; Van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and …

2023AlgemeenArtikel

Stromal vascular fraction-enriched fat grafting as treatment of adherent scars

Vriend, Linda; van Dongen, Joris A; Pijpe, Anouk; Nieuwenhuis, Marianne K. (Healthy Ageing, Allied Health Care And Nursing); Jongen, Sandra J.M.; Harmsen, Martin C; van Zuilen, Paul P.M.; van der Lei, Berend

BACKGROUND: In the last decades, autologous fat grafting has been used to treat adherent dermal scars. The observed regenerative and scar-reducing properties have been mainly ascribed to the tissue-derived stromal vascular fraction (tSVF) in adipose tissue. Adipose tissue's components augment local angiogenesis …

2022-12-01AlgemeenArtikel

Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [11C]Telmisartan

van der Hoek, Sjoukje; Mulder, Douwe J.; T.M. Willemsen, Antoon; Visser, Ton J.; Heeres, André (Biobased Chemistry & Refinery); Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J. L.; Stevens, Jasper

The angiotensin receptor blocker telmisartan slows progression of kidney disease in patients with type 2 diabetes (T2D), yet many patients remain at high risk for progressive kidney function loss. The underlying mechanisms for this response variation might be attributed to differences in angiotensin-1 …

2022-09-07AlgemeenArtikel

A guide for standardized interpretation of lumbar multifidus ultrasonography; an observational study

Soer, (Remko) (Associate Lector); Wolff, A.P. (André) (Professor); Hofste, A. (Anke) (Phd); Ravensberg, R. (Ricardo) van (Onderzoeker); Hermens, (Hermie ) (Extern); Groen, (Gerbrand ) (Extern); Oosterveld, (Frits ) (Onderzoeker); Corporaal, (Stephan) (Lector); Herik-Jonker, (Marie-José) (Extern)

Background Inconsistent descriptions of Lumbar multifidus (LM) morphology were previously identified, especially in research applying ultrasonography (US), hampering its clinical applicability with regard to diagnosis and therapy. The aim of this study is to determine the LM-sonoanatomy by comparing …

2022-07-01AlgemeenArtikel

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