Background: Many intervention development projects fail to bridge the gap from basic research to clinical practice. Instead of theory-based approaches to intervention development, co-design prioritizes the end users' perspective as well as continuous collaboration between stakeholders, designers, and …

by using the design thinking method research is done to find out how audio impacts the user experience and what ways there are for the implementation of audio. A prototype, featuring an Augmented Reality will be built and used as a way of testing. The results indicate that for the implementation of audio …

Fossil fuels have greatly affected the world. How we move around in our cars, how we produce and consume our food, how we keep our economy running, generate electricity and spatialize our cities. But whether we like it or not, we are moving towards a future without these fossil fuels ¬– an era in which …

In a design and research studio of the Amsterdam Academy of Architecture six students investigated between September and December 2020 the transition to that post-fossil era, we visualized the expression of the post-fossil city of the future, we explored systems and solutions that we cannot yet imagine. …

Introduction: There is a lack of effective interventions available for Pediatric Physical Therapists (PPTs) to promote a physically active lifestyle in children with physical disabilities. Participatory design methods (co-design) may be helpful in generating insights and developing intervention prototypes …

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells …

Purpose: Dietary nitrate has been shown to enhance muscle contractile function and has, therefore, been linked to increased muscle power and sprint exercise performance. However, the impact of dietary nitrate supplementation on maximal strength, performance and muscular endurance remains to be established. …