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Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Frijters, Raoul; Fleuren, Wilco; Toonen, Erik J M; Tuckermann, Jan P; Reichardt, Holger M; van der Maaden, Hans; van Elsas, Andrea; van Lierop, Marie-Jose; Dokter, Wim; de Vlieg, Jacob; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

2010-06-05AlgemeenArtikel

Front-of-pack nutrition label stimulates healthier product development

Vyth, E.L.; Steenhuis, I.H.M.; Roodenburg, A.J.C.; Brug, J.; Seidell, J.C.

In addition to helping consumers make healthier food choices, front-of-pack nutrition labels could encourage companies to reformulate existing products and develop new ones with a healthier product composition. This is the largest study to date to investigate the effect of a nutrition logo on the development …

2010Mens & MaatschappijArtikel

Using intervention mapping (IM) to develop a self-management program for employees with a chronic disease in the Netherlands

Sarah Detaille; J. van der Gulden; Josephine Engels; Yvonne Heerkens; F. van Dijk

Employees with a chronic disease often encounter problems at work because of their chronic disease. The current paper describes the development of a self-management programme based on the Chronic Disease Self-Management programme (CDSMP) of Stanford University to help employees with a chronic somatic …

2010AlgemeenArtikel

Hand-held dynamometry in patients with haematological malignancies: Measurement error in the clinical assessment of knee extension strength

N.K. Aaronson; Geert Aufdemkampe (Docent); D. Uebelhart; E.D. de Bruin; R.H. Knols

No summary available

2009AlgemeenArtikel

Risk factors for delirium in intensive care patients: a prospective cohort study

S. Truijen; M.M. Elseviers; L.M. Shortridge-Baggett; B. van Rompaey; Prof. Dr. M.J. Schuurmans (Lector)

No summary available

2009AlgemeenArtikel

The design of the SAFE or SORRY? study : A cluster randomised trial on the development and testing of an evidence based inpatient safety program for the prevention of adverse events

Betsie van Gaal; Theo van Achterberg; Marlies Hulscher; George Borm; Joke Mintjes; R.T. Koopmans; Lisette Schoonhoven

Patients in hospitals and nursing homes are at risk of the development of, often preventable, adverse events (AEs), which threaten patient safety. Guidelines for prevention of many types of AEs are available, however, compliance with these guidelines appears to be lacking. Besides general barriers that …

2009AlgemeenArtikel

BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

Hulsen, Tim; de Vlieg, Jacob; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: In many genomics projects, numerous lists containing biological identifiers are produced. Often it is useful to see the overlap between different lists, enabling researchers to quickly observe similarities and differences between the data sets they are analyzing. One of the most popular methods …

2008-10-16AlgemeenArtikel

A Comparison of the CAM-ICU and the Neecham Confusion Scale in intensive care delirium assessment: an observational study in non-intubated patients.

L.M. Shortridge-Baggett; M. Elseviers; L. Bossaert; Prof. Dr. M.J. Schuurmans (Lector); B. van Rompaey; S. Truien

No summary available

2008AlgemeenArtikel

Passive movement therapy in patients with moderate to severe paratonia; study protocol of a randomised clinical trial (ISRCTN43069940)

Hobbelen, Johannes S M (Ageing And Allied Health Care); Verhey, Frans R J; Bor, Jacobus H J; de Bie, Rob A; Koopmans, Raymond T C M

BACKGROUND: Paratonia, a form of hypertonia, is associated with loss of mobility and with the development of contractures especially in the late stages of the dementia. Passive movement therapy (PMT) currently is the main physiotherapeutic intervention. General doubt about the beneficial effects of this …

2007-12-19AlgemeenArtikel

The NEECHAM Confusion Scale and the Delirium Observation Screening Scale: Capacity to discriminate and ease of use in clinical practice.

Prof. Dr. M.J. Schuurmans (Lector); L.A. van Gemert

BACKGROUND: Delirium is a frequent form of psychopathology in elderly hospitalized patients; it is a symptom of acute somatic illness. The consequences of delirium include high morbidity and mortality, lengthened hospital stay, and nursing home placement. Early recognition of delirium symptoms enables …

2007-05AlgemeenArtikel

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