OBJECTIVE: PRECIS - 2 is a tool that could improve design insight for trialists. Our aim was to validate the PRECIS - 2 tool, unlike its predecessor, testing the discriminant validity and inter-rater reliability. STUDY DESIGN AND SETTING: Over 80 international trialists, methodologists, clinicians and …

Extrudate swell simulations and experiments have been performed with a viscoelastic tire rubber compound at high flow rates through a circular die. A 3-mode PTT model was fitted onto rheological data of the rubber. The PTT model covers the range of shear rates present in the simulation. Convergence of …

Evaluating protein kinetics in the critically ill population remains a very difficult task. Heterogeneity in the intensive care unit (ICU) population and wide spectrum of disease processes creates complexity in assessing protein kinetics. Traditionally, protein has been delivered in the context of total …

From the thesis: "Summary Metabolic diseases that are characterized by a disturbance in energy balance because of feeding behavior, such as obesity and anorexia are known to be a world-wide problem. A better understanding in central regulation of energy intake and metabolism could give more insight in …

Floods are the most damaging natural hazard in the world. Better understanding on the flood hazard phenomenon and its potential consequences in our society is crucial for the development of flood control policies, risk reduction projects and other types of flood management strategies. Ho Chi Minh city …

The primary aims of this study were (1) to evaluate whole-body mechanical efficiency (ME) in a large group of chronic obstructive pulmonary disease (COPD) patients with a wide range of degrees of illness and (2) to examine how ME in COPD is related to absolute work rate and indices of disease severity …

The development of the World Wide Web, the emergence of social media and Big Data have led to a rising amount of data. Information and Communication Technologies (ICTs) affect the environment in various ways. Their energy consumption is growing exponentially, with and without the use of ‘green’ energy. …

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

Today’s military missions are often broad in scope and face a multitude of political, socio-economic, and security challenges. Enemy-centric intelligence is therefore no longer sufficient. Based on their experiences in Afghanistan, retired General Michael T. Flynn and his colleagues noted that U.S. …

International conflict resolution increasingly involves the use of non-military power and non-kinetic capabilities alongside military capabilities in the face of hybrid threats. In this book, counter-measures to those threats are addressed by academics with both practical and theoretical experience and …