Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

Background: Recent transitions in long-term care in the Netherlands have major consequences for community- dwelling older adults. A new paradigm expects them to manage and arrange their own care and support as much as possible. Technology can support this shift. A study has been conducted to explore …

Personalization, production on-demand, and flexible manufacture facilities are growing within the European apparel sector, supported by national and regional public policy. These developments seem to embody a much waited “paradigm shift” in the fashion industry; a shift from global to local scale, from …

Objective To describe longitudinal change in perceived health, presence of health issues, and functional level in adults with cerebral palsy (CP). Design Prospective cohort study. Setting Participants' daily environment. Participants Adults (N=49) with CP (age range, 35–45y; 27 [55%] men; 36 [75%] …

Aim To explore the course of employment in adults with cerebral palsy (CP) over 14 years, and to identify subgroups at risk for unemployment. Method Sixty‐five adults with CP (33 males, 32 females; baseline age 25y 8mo, standard deviation [SD] 3y 2mo; intellectual impairment 25%; bilateral CP 65%) participated …

The primary aims of this study were (1) to evaluate whole-body mechanical efficiency (ME) in a large group of chronic obstructive pulmonary disease (COPD) patients with a wide range of degrees of illness and (2) to examine how ME in COPD is related to absolute work rate and indices of disease severity …

A commentary on: Older adults can improve compensatory stepping with repeated postural perturbations by Dijkstra,B.W., Horak,F.B., Kamsma,Y.P.T., and Peterson,D.S.(2015).Front.AgingNeurosci. 7:201. doi:10.3389/fnagi.2015.00201. In sum, the results of Dijkstra etal. (2015) are of importance and significance …

Objectives: to compare changes over time in the in-hospital mortality and the mortality from discharge to 30 days post-discharge for six highly prevalent discharge diagnoses in acutely admitted older patients as well as to assess the effect of separately analysing the in-hospital mortality and the mortality …

Diminishing motor function is commonly observed in the elderly population and is associated with a wide range of adverse health consequences. Advanced Glycation End products (AGE’s) may contribute to age-related decline in the function of cells and tissues in normal ageing. Although the negative effect …

Objectives: Many older adults have significant depressive symptoms but few people access care for these. This study explores which personal, clinical and need factors facilitate or hinder acceptance of a new outreaching preference-led intervention programme. Methods: From a sample of 9661 community-dwelling …