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Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection

Paul G. Werthmann (Onderzoeker); Pia Inter (Onderzoeker); Thilo Welsch (Onderzoeker)

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)—widely used as an adjunct to cancer treatment—have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically …

2018-10-22GezondheidArtikel

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Stef J. Koppelman (Onderzoeker); Mieke Smits (Lid Lectoraat); Monic Tomassen (Onderzoeker); Govardus A.H. de de Jong (Onderzoeker); Joe Baumert (Onderzoeker); Steve L. Taylor (Onderzoeker); Renger Witkamp (Onderzoeker); Robert Jan Veldman (Lid Lectoraat); Raymond Pieters (Lector); Harry Wichers (Onderzoeker)

from the article: "Abstract: The oral mucosa is the first immune tissue that encounters allergens upon ingestion of food. We hypothesized that the bio-accessibility of allergens at this stage may be a key determinant for sensitization. Light roasted peanut flour was suspended at various pH in buffers …

2018-09-11GezondheidArtikel

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation

Marija Perusko (Onderzoeker); Manon van Roest (Onderzoeker); Dragana Stanic-Vucinic (Onderzoeker); Peter J. Simons (Onderzoeker); Raymond Pieters (Lector); Tanja Cirkovic-Velickovic (Onderzoeker); Joost Smit (Onderzoeker)

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

2018GezondheidArtikel

DiAgRaMs: selecting biomarkers for gut-permeability

Smelt, Maaike

Increased intestinal permeability is linked to both intestinal as well as peripheral inflammatory disease. Contact between intestinal contents and the underlying immune system may account for excessive immune activation and local as well as systemic inflammation. Decreasing intestinal permeability using …

2017-12-19AlgemeenConferentiebijdrage

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer

Anja Thronicke (Onderzoeker); Megan L. Steele (Onderzoeker); Christian Grah (Onderzoeker); Burkhard Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and …

2017-12-13GezondheidArtikel

The intensive care medicine research agenda in nutrition and metabolism

Arabi, Yaseen M; Casaer, Michael P.; Chapman, Marianne; Heyland, Daren K.; Ichai, Carole; Marik, Paul E.; Martindale, Robert G.; McClave, Stephen A.; Preiser, Jean-Charles; Reignier, Jean; Rice, Todd W.; Van den Berghe, Greet; van Zanten, Arthur R. H.; Weijs, Peter J. M. (Lectoraat Voeding En Beweging)

PURPOSE: The objectives of this review are to summarize the current practices and major recent advances in critical care nutrition and metabolism, review common beliefs that have been contradicted by recent trials, highlight key remaining areas of uncertainty, and suggest recommendations for the top …

2017-09AlgemeenAndersoortig materiaal

The impact of protein quantity during energy restriction on genome-wide gene expression in adipose tissue of obese humans

Van Bussel, I P G; Backx, E M P; De Groot, C P G M; Tieland, M (Lectoraat Voeding En Beweging); Müller, M; Afman, L A

BACKGROUND: Overweight and obesity is a growing health problem worldwide. The most effective strategy to reduce weight is energy restriction (ER). ER has been shown to be beneficial in disease prevention and it reduces chronic inflammation. Recent studies suggest that reducing the protein quantity of …

2017-07AlgemeenArtikel

Protein Kinetics and Metabolic Effects Related to Disease States in the Intensive Care Unit

Martindale, Robert G.; Heyland, Daren K.; Rugeles, Saúl J.; Wernerman, Jan; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Patel, Jayshil J.; McClave, Stephen A.

Evaluating protein kinetics in the critically ill population remains a very difficult task. Heterogeneity in the intensive care unit (ICU) population and wide spectrum of disease processes creates complexity in assessing protein kinetics. Traditionally, protein has been delivered in the context of total …

2017-04AlgemeenArtikel

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