The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

BACKGROUND: Instability of the knee joint during gait is frequently reported by patients with knee osteoarthritis or an anterior cruciate ligament rupture. The assessment of instability in clinical practice and clinical research studies mainly relies on self-reporting. Alternatively, parameters measured …

Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse …

BACKGROUND: Causes of anterior cruciate ligament (ACL) injuries are multifactorial. Anterior cruciate ligament injury prevention should thus be approached from a multifactorial perspective as well. Training to resist fatigue is an underestimated aspect of prevention programs given that the presence of …

In collaboration with Eindhoven University of Technology, the goal is to synthesize water-soluble supramolecular fiber components (hydrogels) based on the BTA for mimicking the ECM. Is these BTA components the tetraethylene glycol units would be replaced by mono- or disaccharides, e.g. glucose or cellobiose. …

Purpose: The purpose of this systematic review was to assess whether LBP patients demonstrate signs of splinting by evaluating the reactions to unexpected mechanical perturbations in terms of (1) trunk muscle activity, (2) kinetic and (3) kinematic trunk responses and (4) estimated mechanical properties …

Aanleiding Instabiliteit van het glenohumerale (GH)-gewricht is een veelvoorkomende blessure bij jonge, actieve sporters. De gegenereerde prevalentie van GH-instabiliteit is 0.12 per 1000 sportmomenten. Een gevolg van instabiliteit van het GH-gewricht kan luxatie zijn. Bij anterieure schouderluxatie …

Understanding the nature of the war, and the broader strategic and operational environment is of great importance for effective decision-making. However, most of today ’ s military missions are multidimensional having military, political, economic, and judicial aims. As a result, military organizations …