Background: Pseudomonas aeruginosa is a nosocomial pathogen that causes severe infections in immunocompromised patients. Biofilm plays a significant role in the resistance of this bacterium and complicates the treatment of its infections. In this study, the effect of lyticase and β-glucosidase enzymes …

Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human diferences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: …

Coastal tourism and recreation are one of the most rapidly growing fields worldwide and people spend more time outdoors. Skin protection is, in this respect, important to prevent severe skin damage and skin aging. The past decades the awareness and the importance of skin protection against long time …

Daily life is greatly influenced by fossil fuels. New technological inventions and the reduction of the ice coverage due to climate change makes it possible for humans to be present and undertake activities, such as gathering oil in previously inaccessible areas like the North Pole (Sagerup, Nahrgang, …

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

nd co-authors , William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc De Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matt Martin, Mary Ellen McNerney, Christine …

From the article: Abstract Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic …

Purpose. So-called spontaneous remissions in cancer often seem to occur after febrile events. Mistletoe preparations (MPs) are used off-label intravenously to induce fever within concepts of integrative oncology. We wanted to investigate the frequency of febrile reactions and safety related to intravenously …

Tropical forest in Tabalong district South Kalimantan are under threat by external factors; one of the main threats to the forests are coal mining operations. Coal mining operations are temporary land use activities because of this mine rehabilitation is an important part of the mine development process.Mine …

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use of …