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Why is it so difficult to prove that rapid response systems improve patient outcome? : Directions for further research

Hans van der Hoeven; B.G. Fikkers; Lisette Schoonhoven; Joke Mintjes; Friede Simmes

The implementation of rapid response systems (RRS) is based on the knowledge that deteriorating physiological processes are frequently present for hours or days before clear clinical deterioration is recognized [1,2]. It is assumed that this physiological deterioration is often treatable and that treatment …

2012AlgemeenArtikel

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

Duiker, E.; van der Heij-Meijer, Annemieke; van der Bilt, A. R. M.; Meersma, G.J.; Kooi, N.; van der Zee, A.G.J.; de Vries, E.G.E.; de Jong, Steven

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

2011-04-01AlgemeenArtikel

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Why is it so difficult to prove that rapid response systems improve patient outcome? : Directions for further research

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

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