Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

Anthropogenic changes to estuaries, usually highly productive systems, may result in increased turbidity levels, suppress pelagic primary production and negatively affect ecosystem functions. The Ems-Dollard estuary, enclosed between the Netherlands and Germany, is such an estuary with a long history …

Lipoedema is a painful non-pitting diffuse “fatty” swelling, usually confined to the legs, that occurs mainly in women. This scoping review aimed to provide an overview of the available research on the functioning of people with lipoedema, according to the International Classification of Functioning, …

BACKGROUND: The population of elderly patients with burn injuries is growing. Insight into long-term mortality rates of elderly after burn injury and predictors affecting outcome is limited. This study aimed to provide this information. METHODS: A multicentre observational retrospective cohort study …

The long spined sea urchin Diadema antillarum was an abundant grazer on Caribbean coral reefs, until 1983–1984, when densities were reduced by ∼98% during a region wide die-off. Since then, there has been very little natural recovery of the species and interest is growing in applying aquaculture as a …

INTRODUCTION: Entrustable professional activities (EPAs) are used during training but may also have significance after graduation. This domain has not yet been much explored. We investigated the use of EPAs among alumni of Master Physician Assistant programs in the Netherlands, where EPAs have been used …

Blockchains draw everything they touch into a market logic. Is resistance possible?Activist and artistic engagements with blockchain technology point to (at least) threedifferent sets of tactics that aim to subvert this affordance of the technology. The firstis part of an accellerationist logic: riding …

Background: Team-based palliative care interventions have shown positive results for patients at the end of life in both hospital and community settings. However, evidence on the effectiveness of transmural, that is, spanning hospital and home, team-based palliative care collaborations is limited. Aim: …

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

Background The primary objective of this study is to identify which modifiable and non-modifiable factors are independent predictors of the development of chronic pain in patients with acute- or subacute nonspecific idiopathic, non-traumatic neck pain, and secondly, to combine these to develop and internally …