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Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Seinen, Jolien; Engelke, Rudolf; Abdullah, Mohammed R; Voß, Franziska; Michalik, Stephan; Dhople, Vishnu M; Dieperink, Willem; de Smet, Anne Marie G A; Völker, Uwe; van Dijl, Jan Maarten; Schmidt, Frank; Hammerschmidt, Sven

Respiratory pathogens like Streptococcus pneumoniae can cause severe pneumonia. Nonetheless, mechanically ventilated intensive care patients, who have a high risk of contracting pneumonia, rarely develop pneumococcal pneumonia. Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, …

2021-04-27AlgemeenArtikel

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

HOT-ICU Investigators

Abstract Background Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targ...

2021-04-08AlgemeenArtikel

Associations of body mass index with ventilation management and clinical outcomes in invasively ventilated patients with ARDS Related to COVID-19

PRoVENT-COVID

We describe the practice of ventilation and mortality rates in invasively ventilated normal-weight (18.5 ≤ BMI ≤ 24.9 kg/m2), overweight (25.0 ≤ BMI ≤ 29.9 kg/m2), and obese (BMI > 30 kg/m2) COVID-19 ARDS patients in a national, multicenter observational study, performed at 22 intensive care units in …

2021-03-11AlgemeenArtikel

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID)

Stilma, W. (Faculteit Gezondheid)

BACKGROUND: Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak. METHODS: …

2021-02-01AlgemeenArtikel

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID)

PRoVENT-COVID

2021-02-01AlgemeenArtikel

Malnutrition Prevalence Rates among Dutch Nursing Home Residents: What Has Changed over One Decade? A Comparison of the Years 2009, 2013 and 2018

IHJ Everink; JCM van Haastregt; M Manders; Marian de van der Schueren; JMGA Schols

Objectives To assess changes in prevalence of malnutrition and its associated factors among people living in Dutch nursing homes in 2009, 2013 and 2018. Design Secondary data analysis of the International Prevalence Measurement of Care Quality (LPZ) study. Setting Dutch nursing homes. Participants Residents …

2021AlgemeenArtikel

The Impact of Nursing Delirium Preventive Interventions in the ICU. A multicenter cluster-randomized controlled clinical trial

Paul Rood; M. Zegers; D. Ramnarain; M. Koopmans; T. Klarenbeek; E. Ewalds; M. van der Steen; A. Oldenbeuving; M. Kuiper; S. Teerenstra; E. Adang; L.M. van Loon; A. Wassenaar; H. Vermeulen; P. Pickkers; M. van den Boogaard

2021AlgemeenArtikel

Reporting incidents involving the use of advanced medical technologies by nurses in home care

ten Haken, Ingrid; Ben Allouch, Somaya (Lectoraat Digital Life); Van Harten, Wim H

Background: Advanced medical technologies (AMTs), such as respiratory support or suction devices, are increasingly used in home settings and incidents may well result in patient harm. Information about risks and incidents can contribute to improved patient safety, provided that those are reported and …

2021AlgemeenArtikel

Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers

Stilma, Willemke (Faculteit Gezondheid); Åkerman, Eva; Artigas, Antonio; Bentley, Andrew; Bos, Lieuwe D.; Bosman, Thomas J. C.; de Bruin, Hendrik; Brummaier, Tobias; Buiteman-Kruizinga, Laura A.; Carcò, Francesco; Chesney, Gregg; Chu, Cindy; Dark, Paul; Dondorp, Arjen M.; Gijsbers, Harm J. H.; Gilder, Mary Ellen; Grieco, Domenico L.; Inglis, Rebecca; Laffey, John G.; Landoni, Giovanni; Lu, Weihua; Maduro, Lisa M. N.; McGready, Rose; McNicholas, Bairbre; de Mendoza, Diego; Morales-Quinteros, Luis; Nosten, Francois; Papali, Alfred; Paternoster, Gianluca; Paulus, Frederique (Lectoraat Critical Care); Pisani, Luigi; Prud'homme, Eloi; Ricard, Jean-Damien; Roca, Oriol; Sartini, Chiara; Scaravilli, Vittorio; Schultz, Marcus J.; Sivakorn, Chaisith; Spronk, Peter E.; Sztajnbok, Jaques; Trigui, Youssef; Vollman, Kathleen M.; van der Woude, Margaretha C. E.

Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and …

2021AlgemeenArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

Morales-Quinteros, Luis; Neto, Ary Serpa; Artigas, Antonio; Blanch, Lluis; Botta, Michela; Kaufman, David A.; Schultz, Marcus J.; Tsonas, Anissa M.; Paulus, Frederique; Bos, Lieuwe D.

BACKGROUND: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. METHODS: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021AlgemeenArtikel

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