The architecture of TP 53 , the most frequently mutated gene in human cancer, is more complex than previously thought. Using TP 53 variants as clinical biomarkers to predict response to treatment or patient outcome requires an unequivocal and standardized procedure toward a definitive strategy for the …

The effect of alterations in the processing of proprioceptive signals, on postural control, has been studied using muscle vibration effects. However, reliability and agreement of muscle vibration have still to be addressed.This study aimed to assess intra- and interday reliability and agreement of vibration …

Probiotic bacteria harbor effector molecules that confer health benefits, but also adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. To study these adaptation factors, an antibiotic-resistant derivative of the probiotic model organism Lactobacillus plantarum …

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

In psychiatric care professionals perceive some patients as ‘difficult’, especially patients with long-term non-psychotic disorders. For these patients few evidence-based treatments exist. An intervention program, Interpersonal Community Psychiatric Treatment (ICPT), was developed by the authors. It …

Kooyman Eigen Huis is a real-estate agency that is active in Drechtsteden. It was founded by the two brothers Teun en Henk Kooyman in 1976. The business has been thriving since then. However, the realestate climate has changed and a new strategy needs to be formulated. The company strives to innovate …

Over the past decades, international terrorism started to reach its ideological peak, challenging and disrupting whole societies and governmental organs. This modern form of terror contains violent implications, psychologically pressing the innocent masses. Initially inspired by occasional, domestically …

This paper is based on all text received since the conference was announced late in 2009. Prospective participants were informed that no individual papers were expected but that the conference would be structured around one document, baptized ‘Lead-paper’, that would go through several rounds of amendments, …

The past century has been a century characterized by human suffering and conflict. The establishment of the United Nations in the aftermath of World War II has brought the pressing issue of human rights to the attention of the international world. However, the UN’s reluctance to act on occasions of …

This paper focuses on the concept climate refugees in the 21st Century and mainly concerns environmentally displaced persons from developing countries. It seeks to answer the following question: 'Should the concept of climate refugees best be approached from a juridical or an environmental point of view?' …