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Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

Automatic recognition of self-acknowledged limitations in clinical research literature

Kilicoglu, Halil; Rosemblat, Graciela; Malički, Mario; Ter Riet, Gerben (Faculteit Gezondheid)

Objective: To automatically recognize self-acknowledged limitations in clinical research publications to support efforts in improving research transparency. Methods: To develop our recognition methods, we used a set of 8431 sentences from 1197 PubMed Central articles. A subset of these sentences was …

2018-07AlgemeenArtikel

Measuring program fidelity in case management for high risk families

Busschers, Inge; Boendermaker, Leonieke (Lectoraat Jeugdzorg); Dinkgreve, Marc; Stams, Geert Jan

Abstract Summary: Program fidelity instruments are a key ingredient for clinical supervision and implementation as well as effectiveness studies. This study examines the factor structure of the Functional Family Parole services Global Rating Measure (FFP-GRM); the program fidelity instrument of Functional …

2018AlgemeenArtikel

Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas

Gehring, Karin; Kloek, Corelien JJ; Aaronson, Neil K; Janssen, Kasper W; Jones, Lee W; Sitskoorn, Margriet M; Stuiver, Martijn M

OBJECTIVE: In this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas. DESIGN: Pilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group. SUBJECTS: Patients with stable grade II and III gliomas. …

2017-09AlgemeenArtikel

The PRECIS-2 tool has good interrater reliability and modest discriminant validity

Loudon, Kirsty; Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Gágyor, Ildikó; Hobbelen, Hans (Ageing And Allied Health Care); Althabe, Fernando; Krishnan, Jerry A; Treweek, Shaun

OBJECTIVE: PRECIS - 2 is a tool that could improve design insight for trialists. Our aim was to validate the PRECIS - 2 tool, unlike its predecessor, testing the discriminant validity and inter-rater reliability. STUDY DESIGN AND SETTING: Over 80 international trialists, methodologists, clinicians and …

2017-06-08AlgemeenArtikel

Measurement Properties of Clinical Assessment Methods for Classifying generalized joint hypermobility-A systematic review

Juul-Kristensen, Birgit; Schmedling, Karoline; Rombaut, Lies; Lund, Hans; Engelbert, Raoul H.H.

The purpose was to perform a systematic review of clinical assessment methods for classifying Generalized Joint Hypermobility (GJH), evaluate their clinimetric properties, and perform the best evidence synthesis of these methods. Four test assessment methods (Beighton Score [BS], Carter and Wilkinson, …

2017-03AlgemeenArtikel

Development of a wheelchair mobility skills test for children and adolescents: combining evidence with clinical expertise

Marleen Sol (Lid Lectoraat); Olaf Verschuren; Laura de Groot; Janke de Groot (Lid Lectoraat)

Wheelchair mobility skills (WMS) training is regarded by children using a manual wheelchair and their parents as an important factor to improve participation and daily physical activity. Currently, there is no outcome measure available for the evaluation of WMS in children. Several wheelchair mobility …

2017GezondheidArtikel

Antimicrobial susceptibility testing of Gram-positive and -negative bacterial isolates directly from spiked blood culture media with Raman spectroscopy

H.E. Dekter (Onderzoeker); Claudia Constance Orelio (Onderzoeker); Maarten Morsink (Onderzoeker); S. Tektas (Onderzoeker); B. Vis (Onderzoeker); R. te Witt (Onderzoeker); Willem van Leeuwen (Lector)

Patients suffering from bacterial bloodstream infections have an increased risk of developing systematic inflammatory response syndrome (SIRS), which can result in rapid deterioration of the patients’ health. Diagnostic methods for bacterial identification and antimicrobial susceptibility tests are time-consuming. …

2017Natuur & LandbouwArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Raymond Pieters (Lector)

From the publisher: "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the …

2017GezondheidArtikel

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