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Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation

Marija Perusko (Onderzoeker); Manon van Roest (Onderzoeker); Dragana Stanic-Vucinic (Onderzoeker); Peter J. Simons (Onderzoeker); Raymond Pieters (Lector); Tanja Cirkovic-Velickovic (Onderzoeker); Joost Smit (Onderzoeker)

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

2018GezondheidArtikel

Diabetes gravidarum: zorgen doen we samen

Pieters, WAM (Wendy) (Student)

Inleiding Diabetes gravidarum is een van de meest voorkomende medische complicaties die gedurende de zwangerschap kan ontstaan. Om kwalitatief goede zorg aan patiënten te kunnen verlenen is communicatie tussen patiënt en zorgprofessional essentieel. Educatie is een belangrijk inhoudelijk aspect van …

2017-09-01GezondheidMaster

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Werk aan de winkel! : Terugblik KLS/KennisDC Collegetour

Ineke Pieters; Christiaan van Luik

De Collegetour van het KennisDC Logistiek en KLN van 21 februari 2017, had als thema duurzaamheid. Dit thema werd ingeleid door docent van de Hogeschool van Arnhem en Nijmegen, Reinder Pieters. Hij ging in op de rol van duurzaamheid bij verschillende onderwerpen van logistiek. Er moeten nog stappen gezet …

2017AlgemeenArtikel

Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice

Christiane Hammerschmidt-Kamper (Onderzoeker); Daniel Biljes (Onderzoeker); Katja Merches (Onderzoeker); Irina Steiner (Onderzoeker); Daldrup Thomas (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Raymond Pieters (Lector); Charlotte Esser (Onderzoeker)

From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental …

2017GezondheidArtikel

Benefits: Tradition of Use, Experimental Models and Human Studies to Support Health Claims of Botanicals In Food Supplements containing botanicals

Raymond Pieters (Lector)

From the website of the publisher: "Botanicals, which are basis of many plant food supplements (PFS), constitute the major part of worldwide and historically founded traditional medicines (TM) used to cure diseases and maintain health. A recently published trilogy called “The Art and Science of Traditional …

2017GezondheidBoekdeel

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Raymond Pieters (Lector)

From the publisher: "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the …

2017GezondheidArtikel

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