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Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19

Soares, Madu N.; Eggelbusch, Moritz; Naddaf, Elie; Gerrits, Karin H. L.; van der Schaaf, Marike (Lectoraat Revalidatie In De Acute Zorg); van den Borst, Bram; Wiersinga, W. Joost; van Vugt, Michele; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Murray, Andrew J.; Wüst, Rob C.I.

Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, …

2022-02AlgemeenAndersoortig materiaal

Commentaries on Viewpoint: Do we need to change the guideline values for determining low bone mineral density in athletes?

V. Weijer; L. Hilkens; Naomi Brinkmans; Jan-Willem van Dijk; S. Srivastav; M.A. Gadhvi; R.J. Fernandes; D.P. Filho; M.P. Santos

2022AlgemeenArtikel

Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

AH Stokes; C Planty; J Pion; P Ancian; A Rogue; C Bansard; J Silvano; D Papineau; N Ben Abdeljelil; G Maruggi; HF Song; C Spickler; K Blouin; G Dubois; LA Rodriguez; J Baumeister; AM Steff; E Destexhe

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant …

2022AlgemeenArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

PRoVENT-COVID Study Group

Background: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021-12-01AlgemeenArtikel

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome

PRoVENT-COVID

INTRODUCTION: Patients with COVID-19-related acute respiratory distress syndrome (ARDS) have been postulated to present with distinct respiratory subphenotypes. However, most phenotyping schema have been limited by sample size, disregard for temporal dynamics, and insufficient validation. We aimed to …

2021-12-01AlgemeenArtikel

Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome

BACKGROUND : There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). OBJECTIVE : To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy …

2021-12AlgemeenArtikel

Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients-Insights from the PRoVENT-COVID Observational Study

Stilma, Willemke (Faculteit Gezondheid); van Meenen, David M. P.; Valk, Christel M. A.; de Bruin, Hendrik; Paulus, Frederique (Centre Of Expertise Urban Vitality); Serpa Neto, Ary; Schultz, Marcus J.

We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) in a national, multicenter observational study, …

2021-10AlgemeenArtikel

Mortality associated with early changes in ARDS severity in COVID-19 patients

PRoVENT-COVID

PURPOSE: We investigated changes in ARDS severity and associations with outcome in COVID-19 ARDS patients. METHODS: We compared outcomes in patients with ARDS classified as 'mild', 'moderate' or 'severe' at calendar day 1, and after reclassification at calendar day 2. The primary endpoint was 28-day …

2021-10AlgemeenArtikel

SARS-CoV-2 infection in pregnancy during the first wave of COVID-19 in the Netherlands: a prospective nationwide population-based cohort study (NethOSS)

E.M. Overtoom; A.N. Rosman; J.J. Zwart; T.E. Vogelvang; T. van den Akker; K.W.M. Bloemenkamp

Objective To describe characteristics, risk factors and maternal, obstetric and neonatal outcomes of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design Multi-centre prospective population-based cohort study. Setting Nationwide study in the Netherlands. Population Pregnant …

2021-09-08GezondheidArtikel

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure

PRoVENT-COVID

BACKGROUND: The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease …

2021-08-06AlgemeenArtikel

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