Background: The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both …

The viability of novel network-level circular business models (CBMs) is debated heavily. Many companies are hesitant to implement CBMs in their daily practice, because of the various roles, stakes and opinions and the resulting uncertainties. Testing novel CBMs prior to implementation is needed. Some …

BACKGROUND: Prognostic assessments of the mortality of critically ill patients are frequently performed in daily clinical practice and provide prognostic guidance in treatment decisions. In contrast to several sophisticated tools, prognostic estimations made by healthcare providers are always available …

Inclusive labour contributes to the individual human need to realize a meaningful socially integrated existence. However, we are quite lost on what that could/should look like, if it is to be sustainable for both us and our planet! As impossible as it may be, the formulation of needs on a global level, …

BACKGROUND: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. METHODS: This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted …

Rwanda is landlocked and does not have other resources, so the population depends on agriculture as the main economic activity. It is from agriculture that the majority of the people get food for their survival. However, people in the country have been practising subsistence agriculture using traditional …

Since the Industrial Revolution, human activity has reinforced climate change to alarming rates and has introduced new stressors such as plastic pollution to the environment. Currently, 4.8 - 12.7 million tons of plastic litters enter the oceans every year. Globally alternatives to replace synthetic-based …

The purpose of the model is to explore the influence of the design of circular business models (CBMs) on CBM viability. The model represents an Industrial Symbiosis Network (ISN) in which a processor uses the organic waste from suppliers to produce biogas and nutrient rich digestate for local reuse. …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …