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Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Frijters, Raoul; Fleuren, Wilco; Toonen, Erik J M; Tuckermann, Jan P; Reichardt, Holger M; van der Maaden, Hans; van Elsas, Andrea; van Lierop, Marie-Jose; Dokter, Wim; de Vlieg, Jacob; Alkema, Wynand

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

2010-06-05AlgemeenArtikel

Monitoring training progress during exercise training in cancer survivors

May, Anne M; van Weert, Ellen; Korstjens, Irene; Hoekstra-Weebers, Josette E; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); Zonderland, Maria L; Mesters, Ilse; van den Borne, Bart; Ros, Wynand J

OBJECTIVE: To examine the use of a submaximal exercise test in detecting change in fitness level after a physical training program, and to investigate the correlation of outcomes as measured submaximally or maximally. DESIGN: A prospective study in which exercise testing was performed before and after …

2010-03-01AlgemeenArtikel

PhyloPat

Hulsen, Tim; Groenen, Peter M A; de Vlieg, Jacob; Alkema, Wynand

Phylogenetic patterns show the presence or absence of certain genes in a set of full genomes derived from different species. They can also be used to determine sets of genes that occur only in certain evolutionary branches. Previously, we presented a database named PhyloPat which allows the complete …

2009-01-01AlgemeenArtikel

Long-term effects on cancer survivors' quality of life of physical training versus physical training combined with cognitive-behavioral therapy

May, Anne M; Korstjens, Irene; van Weert, Ellen; van den Borne, Bart; Hoekstra-Weebers, Josette E H M; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); Mesters, Ilse; Passchier, Jan; Grobbee, Diederick E; Ros, Wynand J G

BACKGROUND: We compared the effect of a 12-week group-based multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) and cognitive-behavioral therapy (once weekly) with the effect of 12-week group-based physical training (twice weekly) on cancer survivors' …

2008-10-25AlgemeenArtikel

BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

Hulsen, Tim; de Vlieg, Jacob; Alkema, Wynand

BACKGROUND: In many genomics projects, numerous lists containing biological identifiers are produced. Often it is useful to see the overlap between different lists, enabling researchers to quickly observe similarities and differences between the data sets they are analyzing. One of the most popular methods …

2008-10-16AlgemeenArtikel

Quality of life after self-management cancer rehabilitation

Korstjens, Irene; May, Anne M; van Weert, Ellen; Mesters, Ilse; Tan, Frans; Ros, Wynand J G; Hoekstra-Weebers, Josette E H M; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); van den Borne, Bart

OBJECTIVE: To conduct a randomized controlled trial and compare the effects on cancer survivors' quality of life in a 12-week group-based multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) and cognitive-behavioral training (once weekly) with those of …

2008-05AlgemeenArtikel

The development of an evidence-based physical self-management rehabilitation programme for cancer survivors

van Weert, Ellen; Hoekstra-Weebers, Josette E H M; May, Anne M; Korstjens, Irene; Ros, Wynand J G; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing)

OBJECTIVE: This paper describes the development of a physical training programme for cancer patients. Four related but conceptually and empirically distinct physical problems are described: decreased aerobic capacity, decreased muscle strength, fatigue and impaired role physical functioning. The study …

2008-05AlgemeenArtikel

Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, Simon A W; Shapovalova, Irina V; Jekel, Peter A; Alkema, Wynand B L; Svedas, Vytas K; Janssen, Dick B

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

2008-01-01AlgemeenArtikel

The effect of group cohesion on rehabilitation outcome in cancer survivors

May, Anne M; Duivenvoorden, Hugo J; Korstjens, Irene; van Weert, Ellen; Hoekstra-Weebers, Josette E H M; van den Borne, Bart; Mesters, Ilse; van der Schans, Cees P. (Healthy Ageing, Allied Health Care And Nursing); Ros, Wynand J G

Objective: Group-based physical training interventions have been shown to be effective in increasing quality of life in cancer survivors. Until now, however, the impact of cohesion within the group on intervention outcome has not been investigated. Methods: We examined self-reported individual group …

2007-12-19AlgemeenArtikel

Literature-based compound profiling

Frijters, Raoul; Verhoeven, Stefan; Alkema, Wynand; van Schaik, René; Polman, Jan

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …

2007-11-01AlgemeenArtikel

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