Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight …

Between 2009 and 2013 a project has been executed in the Utrecht region to strengthen the workplace innovation capacity of SMEs (My Company 2.0). The participating companies were asked to fill in a questionnaire on the workplace innovation capacity of the company at two moments: at the beginning (T0) …

Background: Cervical dystonia is characterized by involuntary muscle contractions of the neck and abnormal head positions that affect daily life activities and social life of patients. Patients are usually treated with botulinum toxin injections into affected neck muscles to relief pain and improve control …

Background: Anemia is a serious and highly prevalent co-morbidity in chronic heart failure (HF) patients. Its influence on health-related quality of life (HR-QoL) has rarely been studied, and no data is available regarding the role it plays in hospitalized HF patients. Methods: Baseline data from the …

Artrose is een degeneratieve aandoening van het kraakbeen, waarbij ook de andere structuren in de gewrichten betrokken zijn. De aandoening kan leiden tot beperkingen in het dagelijks functioneren. De huidige kennis betreffende de effecten van artrose op arbeidsparticipatie is onvolledig. In de literatuur …

BACKGROUND: Depression in later life is a common mental disorder with a prevalence rate of between 3% and 35% for minor depression and approximately 2% for Major Depressive Disorder (MDD). The most common treatment modalities for MDD are antidepressant medication and psychological interventions. Recently, …

Background: Paratonia causes severe movement dysfunction in late stage dementia. Passive Movement Therapy (PMT) is often used to decrease high muscle tone, but the efficacy has never been shown. The objective of this study is to investigate the effect of PMT on muscle tone after two and four weeks of …

Objectives To evaluate the feasibility and validity of gait parameters measured with an electronic walkway system in predicting short-term fall risk in nursing home residents with dementia. Methods 57 ambulatory nursing home residents with moderate to severe dementia participated in this prospective …

Objective: Multimorbidity is known for its negative effects on health related functioning. It remains unclear if these effects are stable over time. The aim was to investigate if the relation between single morbidity/multimorbidity and health related functioning is temporary or persistent. Methods: Data …

Rapid response systems (RRSs) are considered an important tool for improving patient safety. We studied the effect of an RRS on the incidence of cardiac arrests and unexpected deaths. Retrospective before- after study in a university medical centre. We included 1376 surgical patients before (period 1) …