According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

Study Type – Aetiology (individual cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular …

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

With co-founder Julian Assange garnering everything from a messianic following to derision and calls to be ‘hunted down like a terrorist', Florian Cramer and Ted Byfield stand in opposing corners of the WikiLeaks ring to debate its impact on the modern state.

Optimal postural control is an essential capacity in daily life and can be highly variable. The purpose of this study was to investigate if young people have the ability to choose the optimal postural control strategy according to the postural condition and to investigate if non-specific low back pain …

Background The relative number of children meeting the minimal required dose of daily physical activity remains execrably low. It has been estimated that in 2015 one out of five children will be overweight. Therefore, low levels of physical activity during early childhood may compromise the current and …

There are currently about 6 million – mainly older – people with dementia in the European Union. With ageing, a number of sensory changes occur. Dementia syndrome exacerbates the effects of these sensory changes and alters perception of stimuli. People with dementia have an altered sensitivity for indoor …

The prejudice and discrimination against Roma started upon arrival in the 11th century. They were seen as untrustworthy due to the nomadic lifestyle and different skin colour. Roma were forced to live as slaves during the 1500 which ended several centuries later in 1864. Although, legally they were …

Introduction (author supplied) : In this paper we propose future mapping, an alternative approach to futures research. With future mapping we intend to overcome some of the main problems that we encountered when applying scenario thinking in the area of product design and innovation. Future mapping attempts …

Doel en methode Doel van dit onderzoek was om antwoord te geven op 2 hoofdvragen, namelijk of er sprake is van krachtverlies van perifere skeletspieren bij COPD-patiënten en wat de aanbevelingen zijn voor een trainingsprogramma. Om dit doel te bereiken is er naar literatuur gezocht op internet en in …