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Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand (Data Science For Life Science & Health)

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand (Data Science For Life Science & Health); Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

Best evidence-based physical therapy treatment folowing rTSA

Dieuwke Hettinga

Introduction: the purpose of this study was to examine wath the best evidence-based physical therapy treatment following reversed total shoulder arthroplasty is. Method: A systematic search to relevant scientific articles has been held in Pubmed, Cinahl and PEDro to articles concerning rTSA with the …

2012GezondheidBachelor

Hoe beïnvloedt de biomechanica van de unilaterale, transtibiale amputatiepatiënt het risico op osteo-arthritis?

Dionysia Kalee

Introductie: Dit artikel beschrijft de relatie tussen de biomechanica van de traumatische, unilaterale transtibiale amputiepatiënt en het relatieve risico op de ontwikkeling van osteo-arthritis aan de niet-aangedane zijde, naar aanleiding van een literatuuronderzoek met recente literatuur van 1998 tot …

2012AlgemeenBachelor

Are persons with rheumatoid arthritis deconditioned? A review of physical activity and aerobic capacity

Harriët Wittink (Lector); Tjerk Munsterman; Tim Takken

Background: Although the general assumption is that patients with rheumatoid arthritis (RA) have decreased levels of physical activity, no review has addressed whether this assumption is correct. Methods: Our objective was to systematically review the literature for physical activity levels and aerobic …

2012GezondheidArtikel

Validation of a New Pediatric Joint Scoring System From the International Hemophilia Prophylaxis Study Group: Validity of the Hemophilia Joint Health Score

Feldman, Brian M.; Funk, Sharon M.; Bergstrom, Britt-Marie; Zourikian, Nichan; Hilliard, Pamela; van der Net, JanJaap; Engelbert, Raoul; Petrini, Pia; van den Berg, H. Marijke; Manco-Johnson, Marilyn J.; Rivard, Georges E.; Abad, Audrey; Blanchette, Victor S.

OBJECTIVE: Repeated hemarthrosis in hemophilia causes arthropathy with pain and dysfunction. The Hemophilia Joint Health Score (HJHS) was developed to be more sensitive for detecting arthropathy than the World Federation of Hemophilia (WFH) physical examination scale, especially for children and those …

2011-02AlgemeenArtikel

The six-minute walk test in paediatric populations

Janke de Groot (Lid Lectoraat)

The six-minute walk test (6MWT) is a self-paced, submaximal exercise test used to assess functional exercise capacity in patients with chronic diseases (Chang 2006, Solway et al 2001). It has been used widely in adults, and is being utilised increasingly in paediatric populations; it has been used as …

2011GezondheidArtikel

Self-reported functional status as predictor of observed functional capacity in subjects with early osteoarthritis of the hip and knee

Bieleman, H J; Reneman, M F; van Ittersum, Miriam (Digital Health); van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); Groothoff, J W; Oosterveld, F G J

OBJECTIVES: Patients with hip or knee osteoarthritis (OA) may experience functional limitations in work settings. In the Cohort Hip and Cohort Knee study (CHECK) physical function was both self-reported and measured performance-based, using Functional Capacity Evaluation (FCE). Relations between self-reported …

2009-12AlgemeenArtikel

Illness perceptions in patients with fibromyalgia

van Ittersum, M W; van Wilgen, C P; Hilberdink, W K H A; Groothoff, J W; van der Schans, C.P. (Healthy Ageing, Allied Health Care And Nursing)

OBJECTIVE: Former studies in chronic diseases showed the importance of patients' beliefs and perceptions. The Revised Illness Perception Questionnaire was developed to assess these illness perceptions. Our goal was to investigate psychometric properties of the IPQ-R for Fibromyalgia Dutch language version …

2009-01-01AlgemeenArtikel

Common prognostic factors of work disability among employees with a chronic somatic disease: a systematic review of cohort studies.

Sarah Detaille; Yvonne Heerkens; Josephine Engels; J.W. van der Gulden; F.J. van Dijk

OBJECTIVE: Based on prospective and retrospective disease cohort studies, the aim of this review was to determine common prognostic factors for work disability among employees with rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, diabetes mellitus, and ischemic heart disease (IHD). …

2009AlgemeenArtikel

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