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Which are the best conservative interventions for lymphoedema after breast cancer surgery?

Stuiver, Martijn M (Faculteit Gezondheid); ten Tusscher, Marieke R; McNeely, Margaret L

Lymphoedema is a common complication of breast cancer surgery with or without adjuvant cancer treatments.1 Fluid accumulates because of damage to the lymphatic system, most commonly after axillary lymph node dissection. Box 1 shows factors associated with lymphoedema. Swelling is commonly in the arm …

2017-06-01AlgemeenArtikel

Clozapine re-exposure after dilated cardiomyopathy

Mariëtte Nederlof (Onderzoeker); Theo WJ Benschop (Onderzoeker); Cornelia Adriana de Vries Feyens (Onderzoeker); Rob Heerdink (Lector)

from the publishers' website: "A 63-year-old woman with diabetes type II and a history of breast cancer was treated with clozapine for her refractory schizophrenia. She developed a dilated cardiomyopathy with an ejection fraction of 25%, a life-threatening event. The cause of heart failure could be multifactorial, …

2017-05-27GezondheidArtikel

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

Bernard Leroy (Onderzoeker); Mandy L. Ballinger (Onderzoeker); Fanny Baran-Marszak (Onderzoeker); Peter Taschner (Lector)

Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

2017-03-14GezondheidArtikel

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

Functional status decline in older patients with breast and colorectal cancer after cancer treatment

van Abbema, Doris; van Vuuren, Arnée; van den Berkmortel, Franchette; van den Akker, Marjan; Deckx, Laura; Buntinx, Frank; van Kampen, Roel; Lambooij, Els; de Boer, Maaike; de Vos-Geelen, Judith; Tjan-Heijnen, Vivianne C

OBJECTIVES: The aim of the present study was to disentangle the impact of age and that of cancer diagnosis and treatment on functional status (FS) decline in older patients with cancer. MATERIALS AND METHODS: Patients with breast and colorectal cancer aged 50-69years and aged ≥70years who had undergone …

2017AlgemeenArtikel

Analyzing cancer forum discussions with text mining

G. van Oortmerssen; S. Raaijmakers; Maya Sappelli; E. Boertjes; S. Verberne; N. Walasek; W. Kraaij

We present a multilingual, open source system for cancer forum thread analysis, equipped with a biomedical entity tagger and a module for textual summarization. This system allows users to investi- gate textual co-occurrences of biomedical entities in forum posts, and to browse through summaries of long …

2017AlgemeenConferentiebijdrage

Validatie van een LC-MS/MS methode voor Tariquidar, Elacridar en een mengsel van substraten voor P-gp en Bcrp1 en toepassing voor in vivo farmacokinetiek studies

Nikkie Venekamp (Student)

Het NKI is een oncologisch onderzoekscentrum waar wetenschappelijk onderzoek gedaan wordt naar verschillende soorten kanker. Op de afdeling Bio-Farmacologie wordt er voornamelijk onderzoek gedaan naar geneesmiddelen, of een combinatie ervan, die hersentumoren bestrijden. Er worden in vitro en in vivo …

2016-11-25TechniekBachelor

Effect of diagnosis with a chronic disease on physical activity behavior in middle-aged women

Dontje, Manon L.; Krijnen, Wim (Statistical Techniques For Applied Research); de Greef, Mathieu; Peeters, Geeske; Stolk, Ronald P.; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); Brown, Wendy

Objective Although regular physical activity is an effective secondary prevention strategy for patients with a chronic disease, it is unclear whether patients change their daily physical activity after being diagnosed. Therefore, the aims of this study were to (1) describe changes in levels of physical …

2016-02AlgemeenArtikel

Calibration and validation of kv-CBCT in room imaging for dose calculation and adaptive radiotherapy

M. A. Palacios; M. Soumokil; T. S. Rosario

Op verzoek van Jelle Scheurleer: Purpose: To investigate the accuracy of dose calculation on cone beam CT (CBCT) data sets after HU-RED calibration and validation in phantom studies and clinical patients. Material and methods: Calibration of HU-RED curves for kV-CBCT were generated for three clinical …

2015-09-04GezondheidArtikel

Diagnostische beeldkwaliteit van de Low Energy opname bij Contrast Enhanced Spectral Mammography in vergelijking met Full Field Digital Mammography

Emmely van Wylick (Student); Rob Vogels (Begeleider)

Achtergrond Contrast Enhanced Spectral Mammograph (CESM) (CESM) is een nieuwe techniek binnen de mammografie die door een Low Energy opname (LE) en een High Energy opname (HE) een gecombineerd beeld geeft waarop een eventuele tumor middels contrast aankleurt. CESM heeft bewezen superieur te zijn aan …

2015GezondheidBachelor

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