The Power to Flex project aims to promote the development of storage possibilities from sustainable energy sources. Hydrogen is opted to be a feasible energy carrier, which can also be stored for prolonged times without further losses and can be transformed into electricity and heat when needed. Producing …

The main objective of this study is to reveal the heterogeneity of cell types hidden in the developed brain organoids. A secondary goal is to discover gene expression differences among these identified cell types between the cells with 22q11.2 DS and healthy controls. The latter is done to get a better …

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

Purpose: Exercise therapy with a focus on muscle strengthening has proven to be effective for the management of knee osteoarthritis (OA). Yet it is not known whether high-intensity resistance training (RT) is more effective in improving upper leg muscle strength and physical performance than low-intensity …

It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

Everything starts with technology. From buildings to a cell phone, and from the heating to the car, technology is everywhere. Because technology is playing an increasingly important role in society, ROC Mondriaan invests in the future. There is an increased demand for graduate engineering students. …

The current configuration of the robotic stearate coating process only supports certain bead sizes, the rest is coated manually. The current configuration lacks capacity and requires a lot of maintenance due to the age of the used robots. To be able to support all bead sizes, increase the daily capacity, …

Due to the depletion of fossil fuel resources and concern about increasing atmospheric CO2 levels, the production of microbial oil as source for energy and chemicals is considered as a sustainable alternative. A promising candidate strain for the production of microbial oil is the oleaginous yeast Schwanniomyces …

Within the Flexnode Plus project the long-term degradation characteristics of a proton exchange membrane (PEM) electrolyzer (5.5 kW, AC, 1 Nm3/h H2) and fuel cell (1.0 kW, DC, 0.9 Nm3/h) was experimentally tested. The electrolyzer unit was operated at various loads and pressures for approximately 750 …