For susceptible children, appropriate education and the right circumstances are of the utmost importance, even more than with "normal" children. In wrong circumstances things can easily go wrong. But under favourable conditions these people can reach the top. A bit like Formula 1 cars, which still have …

In this paper we present a data-driven profiling approach that we have adopted and implemented for a municipality. Our aim was to make profiles transparent and meaningful for citizens, policymakers and authorities so that they can validate, scrutinize and challenge the profiles. Our approach relies on …

Cutaneous melanoma is a type of skin cancer that develops from benign melanocytes to one of the most aggressive types of skin tumors in human. In cutaneous melanoma progression, the metastasis phase is the most challenging phase to treat. To enable earlier treatment options, a better understanding of …

This article describes a relatively straightforward procedure to knock out the gene that encodes the invertase enzyme in baker’s yeast. The SUC2 gene, which encodes for the invertase enzyme, is knocked out by a single-step PCR knock out method. The knockout is subsequently confirmed at the genetic level …

Pseudomonas fluorescens strain SS101 (Pf.SS101) promotes growth of Arabidopsis thaliana, enhances greening and lateral root formation, and induces systemic resistance (ISR) against the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Here, targeted and untargeted approaches were adopted to identify …

Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

BACKGROUND & AIMS: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with …

Since Factor H is the main regulator of the complement system, any dysregulation may result in either uncontrolled complement activation or inhibition. Auto-antibodies against Factor H inhibit the protective function of Factor H on host cells, which are now sensitive for complement activation. It is …

The 2016 scientific meeting of the Human Genome Variation Society (HGVS; http://www.hgvs.org) was held on the 20th of May in Barcelona, Spain, with the theme of “Clinical Interpretation of Variants from Next-Generation Sequencing".

Numerous databases containing information about DNA, RNA, and protein variations are available. Gene‐specific variant databases (locus‐specific variation databases, LSDBs) are typically curated and maintained for single genes or groups of genes for a certain disease(s). These databases are widely considered …