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Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand (Data Science For Life Science & Health)

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

The effect of Porphyromonas gingivalis lipopolysaccharide on pregnancy in the rat

Kunnen, Alina; van Pampus, M.G.; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); Abbas, F.; Faas, M.M.; Aarnoudse, Jan G

OBJECTIVE: Periodontitis, mostly associated with Porphyromonas gingivalis, has frequently been related to adverse pregnancy outcomes. We therefore investigated whether lipopolysaccharides of P. gingivalis (Pg-LPS) induced pregnancy complications in the rat. METHODS: Experiment 1: pregnant rats (day 14) …

2013AlgemeenArtikel

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand (Data Science For Life Science & Health); Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

Linssen, Margot M L; van Raalte, Daniel H; Toonen, Erik J M; Alkema, Wynand (Data Science For Life Science & Health); van der Zon, Gerard C; Dokter, Wim H; Diamant, Michaela; Guigas, Bruno; Ouwens, D Margriet

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

2011-11-01AlgemeenArtikel

Structural surface changes and inflammatory responses against alginate-based microcapsules after exposure to human peritoneal fluid

de Haan, Bart J; Rossi, Alessandra; Faas, Marijke M; Smelt, Maaike J; Sonvico, Fabio; Colombo, Paolo; de Vos, Paul

Microencapsulation of cells is a promising approach to prevent rejection in the absence of immunosuppression. Clinical application, however, is hampered by insufficient insight in factors influencing biocompatibility of the capsules in humans. In the present study we exposed alginate-based capsules prepared …

2011-09-01AlgemeenArtikel

Prednisolone-induced changes in gene-expression profiles in healthy volunteers

Toonen, Erik J M; Fleuren, Wilco W M; Nässander, Ulla; van Lierop, Marie-José C; Bauerschmidt, Susanne; Dokter, Wim H A; Alkema, Wynand (Data Science For Life Science & Health)

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

2011-07-25AlgemeenArtikel

Implementatie van de Surviving Sepsis Campaign bundels : Monitoring van ervaringen

Lilian Vloet; J. Schouten; N. Stevens; Ans Rensen; A. Willems; F. Zeegers

Sepsis komt vaak voor in ziekenhuizen. Ernstige sepsis is verantwoordelijk voor 10 - 20% van alle Intensive Care (IC) opnames en is de belangrijkste doodsoorzaak op niet-cardiale IC?s. De gemiddelde mortaliteit van volwassenen met ernstige sepsis op de IC is 33% en van volwassenen met septische shock …

2011AlgemeenArtikel

Reumatoïde artritis en visolie : wat is de rol van meervoudig onverzadigde vetzuren - hoofdzakelijk visolie - bij het verloop van reumatoïde artritis? : een inventariserend literatuuronderzoek

Barbara Wildeboer (Begeleider); Suzanne van Steijn (Begeleider); Marieke Stapert (Student)

Al eeuwen lang is bekend dat voeding een rol speelt bij ziekten. Sinds 1950 richt de voedingswetenschap zich met name op de invloed van bepaalde nutriënten op ziekten en aandoeningen. Voeding blijkt op veel lichaamsaspecten van invloed te zijn, zo ook op reumatoïde artritis (RA). Dit inventariserend …

2011GezondheidBachelor

Responsiveness of exercise parameters in children with inflammatory myositis

Takken, Tim; van der Net, Janjaap; Engelbert, Raoul H. H.; Pater, Suzanne; Helders, Paul J. M.

OBJECTIVE: Juvenile dermatomyositis (DM) is an inflammatory myopathy in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance, although the precise etiology is unknown. The goal of this study was to investigate …

2008-01-15AlgemeenArtikel

Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13

Scotton, Chris J; Martinez, Fernando O; Smelt, Maaike J; Sironi, Marina; Locati, Massimo; Mantovani, Alberto; Sozzani, Silvano

IL-4 and IL-13 are prototypic Th2 cytokines that generate an “alternatively activated” phenotype in macrophages. We used high-density oligonucleotide microarrays to investigate the transcriptional profile induced in human monocytes by IL-13. After 8-h stimulation with IL-13, 142 genes were regulated …

2005-01-15AlgemeenArtikel

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