Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

OBJECTIVE: To examine the association between sucking patterns and the quality of fidgety movements in preterm infants. STUDY DESIGN: We studied the sucking patterns and fidgety movements of 44 preterm infants (gestational age <35 weeks) longitudinally from 34 weeks' postmenstrual age up to 14 weeks …

The Lotseninsel is a small peninsula situated in the transition area of the Baltic Sea and the Schlei in Northern Germany. The mouth of the Schlei is an ecological important area and is thus protected under several conservation laws. The position of the Lotseninsel amid and surrounded by this ecological …

The Southern cassowary (Casuarius casuarius johnsonii) is a vulnerable species in Northern Australia. Literature research on the cassowary population in Mission Beach, Queensland, revealed the vulnerability by identifying various threats endangering the cassowaries. Those threats were assessed by various …

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

In het innovatieprogramma ‘Het succes van deGebiedsontwikkelaar’ is onderzoek gedaan naarhet competentieprofiel van de sociaalfysieke gebiedsontwikkelaar die bij een gemeente of corporatiewerkt. Onze gebiedsontwikkelaar is betrokkenbij vernieuwingsprojecten in buurten, wijken endorpen. De functiebenamingen …

Spatial planning has become contested ground in Dutch politics. After decades of a broadly shared belief in strategic spatial planning by central government and comprehensive planning by local and regional authorities, the balance of political thought has changed in recent years. The ministry of housing …

Adaptive urban development is the design, construction and continuing evolution of urban areas to anticipate and react to changes in the environment and society. These changes include both processes within the city itself and external developments. It is expected that until 2100 a total of 5 billion …

This research addresses the question on how Delfzijl can take advantage of the dykes referred to recreational activities within the next five years. In order to investigate this problem statement, the elaboration was started with the definition of research questions and secondary research. Here, brochures, …

Many bilingual children have an acquisition delay in their L2, which is easily mistaken for SLI. With the aim to, on the one hand, tackle this 'disentangling problem' and, on the other hand, create adequate expectations regarding bilingual "normal" development, we compared Dutch lexical and grammatical …