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Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Marie Corradi (Onderzoeker); Alyanne M. de Haan (Onderzoeker); Bernard Staumont (Onderzoeker); Aldert H. Piersma (Onderzoeker); Liesbet Geris (Onderzoeker); Raymond H.H. Pieters (Lector); Cyrille A.M. Krul (Lector); Marc A.T. Teunis (Onderzoeker)

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

2022Gezondheid; …Artikel

Evaluation of allied healthcare in patients recovering from Covid-19

Rob A. de Bie (Onderzoeker); Arie C. Verburg (Onderzoeker); Carla Agasi-Idenburg (Onderzoeker); Edith H.C. Cup (Onderzoeker); Carolien Dekker (Onderzoeker); Johanna M. van Dongen (Onderzoeker); Edwin Geleijn (Onderzoeker); Marissa H.G. Gerards (Onderzoeker); Maud Graff (Onderzoeker); Ron van Heerde (Onderzoeker); Hanneke Kalf (Onderzoeker); Marly Kammerer (Onderzoeker); Renée A. Kool (Onderzoeker); Anja de Kruif (Onderzoeker); Hinke M. Kruizenga (Onderzoeker); Marike van der Leeden (Onderzoeker); Ton A.F. Lenssen (Onderzoeker); Willemijn M. Meijer (Onderzoeker); Raymond Ostelo (Onderzoeker); Amber Ronteltap (Onderzoeker); Marike van der Schaaf (Onderzoeker); Sonja van Oers (Onderzoeker); Marian A. E. de van der Schueren (Onderzoeker); Anne I. Slotegraaf (Onderzoeker); Cindy Veenhof (Lector); Thomas J. Hoogeboom (Onderzoeker); Philip J. van der Wees (Onderzoeker)

Objective: To report the study protocol and baseline characteristics of a prospective cohort study to evaluate longitudinal recovery trajectories of patients recovering from COVID-19 who have visited a primary care allied health professional. Design: Report of the protocol and baseline characteristics for …

2022GezondheidArtikel

Interprofessional learning in a student-run dental clinic: The effect on attitudes of students in oral healthcare

Ria Kersbergen; N.H.J. Creugers; Wietske Kuijer; R. Leunissen; B. Pelzer; L. Fluit; Miranda Laurant

The purpose of this study was to gain insight into change in attitudes held by students in oral healthcare about interprofessional learning and collaboration after one year of work in a student-run dental clinic (SRDC). Third- and fourth-year bachelor of dental hygiene students (n = 221) and first- and …

2022AlgemeenArtikel

Automated energy performance diagnosis of HVAC systems by the 4S3F method

A.C. Taal (Docent)

In practice, faults in building installations are seldom noticed because automated systems to diagnose such faults are not common use, despite many proposed methods: they are cumbersome to apply and not matching the way of thinking of HVAC engineers. Additionally, fault diagnosis and energy performance …

2022TechniekConferentiebijdrage

The association between polypharmacy and malnutrition(risk) in older people: A systematic review.

W.E. Kok; E.B. Haverkort; Y.A. Algra; J. Mollema; Vanessa Hollaar; Elke Naumann; Marian de van der Schueren; K Jerković-Ćosić

BACKGROUND & AIM: Malnutrition adversely influences a broad range of physical and psychological symptoms. Although polypharmacy is often mentioned to be associated with malnutrition, especially in older people it is unclear to what extent. The aim of this systematic review was to investigate the extent …

2022AlgemeenArtikel

Comparison of the prevalence of 21 GLIM phenotypic and etiologic criteria combinations and association with 30-day outcomes in people with cancer: A retrospective observational study.

N Kiss; B. Steer; J Loeliger; R. Alizadehsani; L. Edbrooke; I Deftereos; E. Laing; A. Khosravi; Marian de van der Schueren

BACKGROUND & AIMS: The Global Leadership Initiative on Malnutrition (GLIM) criteria require validation in various clinical populations. This study determined the prevalence of malnutrition in people with cancer using all possible diagnostic combinations of GLIM etiologic and phenotypic criteria and determined …

2022AlgemeenArtikel

Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

AH Stokes; C Planty; J Pion; P Ancian; A Rogue; C Bansard; J Silvano; D Papineau; N Ben Abdeljelil; G Maruggi; HF Song; C Spickler; K Blouin; G Dubois; LA Rodriguez; J Baumeister; AM Steff; E Destexhe

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against RSV disease. The ChAd155-RSV vaccine consists of a recombinant …

2022AlgemeenArtikel

The reliability and validity of the perceive, recall, plan and perform assessment in children with a mitochondrial disorder.

Marieke Lindenschot; S. Koene; M.T. Nott; M.W.G. Nijhuis -van der Sanden; I.J.M. de Groot; Esther Steultjens; M.J.L. Graff

PURPOSE: To investigate the reliability and validity of the Perceive, Recall, Plan and Perform System of Task Analysis (PRPP-Assessment) by parent-provided videos of children with mitochondrial disorders. METHODS: Videos of 13 children performing 3-7 activities each were the subject of study, resulting …

2022AlgemeenArtikel

Stratified exercise therapy does not improve outcomes compared with usual exercise therapy in people with knee osteoarthritis (OCTOPuS study): a cluster randomised trial.

J. Knoop; J Dekker; J.M. van Dongen; M van der Leeden; M. de Rooij; W.F. Peter; W. de Joode; L. van Bodegom-Vos; N. Lopuhaä; K.L. Bennell; W.F. Lems; M. van der Esch; T.P. Vliet Vlieland; R.W.J.G. Ostelo

QUESTION: In people with knee osteoarthritis, how much more effective is stratified exercise therapy that distinguishes three subgroups (high muscle strength subgroup, low muscle strength subgroup, obesity subgroup) in reducing knee pain and improving physical function than usual exercise therapy? DESIGN: …

2022AlgemeenArtikel

Implementing a Personalized Physical Therapy Approach (Coach2Move) Is Effective in Increasing Physical Activity and Improving Functional Mobility in Older Adults: A Cluster-Randomized, Stepped Wedge Trial.

W. Heij; L. Sweerts; Bart Staal; S. Teerenstra; E. Adang; P.J. van der Wees; M.W.G. Nijhuis -van der Sanden; T.J. Hoogeboom

OBJECTIVE: The purpose of this study was to assess whether the superior cost-effectiveness of a personalized physical therapy approach (Coach2Move)-which was demonstrated in a previous trial when compared to usual care physical therapy (UCP)-can be replicated in daily clinical practice. METHODS: A multicenter …

2022AlgemeenArtikel

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