Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

While the wide stream of corporate governance literature dominates governance research, less attention is brought to its applicability to SMEs. We propose that a new perspective on governance research is needed to improve our ability to understand the governance mechanisms driving these smaller firms. Note: …

Norms play an important role in international relations. Norms shape behaviour and provide a shared understanding of what is acceptable and what is not. One of the pillars of international relations is sovereignty. The norm of state sovereignty encompasses the norm of territorial integrity. Large-scale …

The SDGs provide an important framework for businesses to address sustainable development and grand challenges (Kolk, Kourula and Pisani, 2017; Montiel et al, 2021) and SMEs, as major contributors to economic and entrepreneurial activity, are key actors in achieving national SDG targets (Sonntag et al, …

A lab-based test setup was developed to simulate a novel droop rate controlled DC bus charging plaza installation in the Netherlands. The system consists of multiple bidirectional DC charging points, a PV array and a bidirectional grid connection. Currently the installed system employs linear droop control …

Failure is a popular topic of research. It has long been a source of study in fields such as sociology and anthropology, science and technology studies, privacy and surveillance, cultural, feminist and media studies, art, theatre, film, and political science. When things go awry, breakdown, or rupture …

BACKGROUND: Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available. AIMS: To investigate the association between frailty and the risk of COVID-19 hospitalization …

Background Variations in communicative participation of children with developmental language disorder (DLD) cannot be wholly explained by their language difficulties alone and may be influenced by contextual factors. Contextual factors may support or hinder communicative participation in children, which …

“Teaching is both an art and a science” (Harrison & Coll, 2008 p.1). Good teaching excites students and cultivates their curiosity to learn more than they are asked. But what if students’ blank faces tell you that the teaching did not land, what can you do? Using an analogy or metaphor to explain the …