Objectives The objective of the manuscript was to describe the natural history of complaints and disability in children diagnosed with joint hypermobility syndrome (JHS)/Ehlers–Danlos-hypermobility type (EDS-HT) and to identify the constructs that underlie functional decline. Methods One hundred and …

Evaluating protein kinetics in the critically ill population remains a very difficult task. Heterogeneity in the intensive care unit (ICU) population and wide spectrum of disease processes creates complexity in assessing protein kinetics. Traditionally, protein has been delivered in the context of total …

Young talented athletes that mature have an increased injury risk. Human movement scientist Alien van der Sluis studied soccer players of the talent development program of FC Groningen and tennis players of the talented development program of the Royal Dutch Lawn Tennis Federation (KNLTB). The soccer …

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

From the publisher: "Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the …

Background: Lipoedema is a chronic disorder of adipose tissue typically involving an abnormal build-up of fat cells in the legs, thighs and buttocks. Occurring almost exclusively in women, it often co-exists with obesity. Due to an absence of clear objective diagnostic criteria, lipoedema is frequently …

Introductie: Wereldwijd staat borstkanker in de top vier van meest voorkomende soorten kanker. Een voorkomende chronische aandoening van de behandeling van borstkanker is (secundair) lymfoedeem in de bovenste ledematen. De Delphin MoistureMeterD compact® (MMDC) is een meetinstrument die lokaal het vochtgehalte …

BACKGROUND AND PURPOSE: Radiotherapy of the head and neck is challenged by the relatively large number of organs-at-risk close to the tumor. Biologically-oriented objective functions (OF) could optimally distribute the dose among the organs-at-risk. We aimed to explore OFs based on multivariable normal …

This paper describes the robustness determination and optimization of L-cysteine addition for total mercury content determination by Instrumental Neutron Activation Analysis (INAA). Instrumental Neutron Activation Analysis is an analysis technique to measure concentrations of chemical elements regardless …

BACKGROUND: Near-infrared spectroscopy (NIRS) measurements of oxygenation reflect O2 delivery and utilization in exercising muscle and may improve detection of a critical exercise threshold. PURPOSE: First, to detect an oxygenation breakpoint (Δ[O2HbMb-HHbMb]-BP) and compare this breakpoint to ventilatory …