Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

Purpose/Objective: Most dose-escalation trials in glioblastoma patients integrate the escalated dose throughout the standard course by targeting a specific subvolume. We hypothesize that anatomical changes during irradiation may affect the dose coverage of this subvolume for both proton- and photon-based …

The recreational use of nitrous oxide (N2O; laughing gas) has largely expanded in recent years. Although incidental use of nitrous oxide hardly causes any health damage, problematic or heavy use of nitrous oxide can lead to serious adverse effects. Amsterdam care centres noticed that Moroccan–Dutch young …

Dit onderzoek gaat over cliënt J, een 6-jarige jongen met internaliserende problemen en een inadequate emotieregulatie vanuit een problematische gehechtheid. Er wordt onderzocht in hoeverre het werken met verhalen binnen dramatherapie een resultaat heeft op de probleemgebieden van de cliënt. Hoofdvraag: In …

Background: Ecstasy (3,4-methylenedioxymethamphetamine (MDMA)) has a relatively low harm and low dependence liability but is scheduled on List I of the Dutch Opium Act (‘hard drugs’). Concerns surrounding increasing MDMA-related criminality coupled with the possibly inappropriate scheduling of MDMA initiated …

"Military organizations tend to think about their overarching strategy in two ways: how their organization will remain relevant and which future operations they must be able to conduct. In the information era, military organizations struggle with the “design capabilities that will offer . . . credible …

De stuurgroep van de DenkTank MDMA-beleid publiceerde eind 2020 een rapport over de ontwikkeling van een rationeel MDMA-beleid. Het rapport is gebaseerd op een objectiverende wetenschappelijke benadering die zich losmaakt van ideologische politieke strijd. Uit een vergelijking van verschillende beleidsopties …

Question: What are the views of patients, close relatives and healthcare professionals on physical activity behaviour in hospital care? Methods: A meta-ethnographic synthesis of qualitative studies was conducted with a lines-of-argument analysis. The methodological quality of included studies was evaluated …

Purpose This study focuses on the functional and psychosocial consequences of facial weakness of patients with facioscapulohumeral muscular dystrophy (FSHD) and how they manage their daily lives. Materials and methods We conducted a qualitative study. Sixteen FSHD patients with varying degrees of facial …