Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) between the first and second wave in the Netherlands. This is a post hoc analysis of two nationwide observational …

This report analyzes the workflow between UX designers, product owners, and developers, and the design system used by UX designers at Studyportals, evaluating its strengths and weaknesses and proposing improvements for a more efficient and collaborative process. It emphasizes the importance of a design …

This research paper concerns the development process of a procedural texturing tool made to facilitate versatility in terms of style and speed up the current texturing workflow of VR Innovations. Research has been done into similar products on the market, as well as the target audience of the product. …

The closing of schools and sports clubs during theCOVID-19 lockdown raised questions about thepossible impact on children’s motor skilldevelopment. Therefore we compared motorcompetence development over a one-year periodamong four different cohorts of primary schoolchildren. A total of 992 children from …

Aims: This systematic review and meta-analysis evaluates the additional effect of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes.  Methods: Embase, Medline, Web of Science and Cochrane …

Abstract This study assessed the efficacy of a co-designed, school-based intervention meant to promote physical activity and fitness among Dutch prevocational secondary students. In a two-year clustered randomized controlled trial, students’ physical activity and fitness was measured by indirect and …

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

What can be done to strengthen the controlling position of APAS in the German Audit industry? 1. How can APAS be compared to the US Public Company Accounting Oversight Board (PCAOB) 2. What are the conclusions that can be drawn from the comparison? 3. What is the Wirecard scandal and how did it unfold? 4. …

Background The work participation of young adults with chronic physical conditions lag behind compared to healthy age-mates. ‘At Work’ is a vocational rehabilitation intervention provided by occupational therapists, that supports them for entering the competitive labour market after graduating post-secondary …