The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse …

Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human diferences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: …