The European Union Artificial Intelligence (AI) Act was adopted in 2024 to protect public interests from AI-related harms. We aimed to determine whether the AI Act captures the most relevant stakeholders’ values for a high-risk AI Clinical Decision Support System (CDSS) for cardiovascular disease. Ethics …

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

Background & aims: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, …

The hip fracture causes significant disabilities in many elderly people. Many studies around the world have identified various risk factors for the hip fracture. The aim of this study was to systematically investigate the risk factors of hip fractures. This study is a systematic review of risk factors …

Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies …

Objective: Patients with chronic limb threatening ischemia (CLTI) are at high risk for amputation and other cardiovascular adverse events. Nutrition-related symptoms and malnutrition are common in the CLTI population, and lead to worse clinical outcomes. Understanding of the factors influencing nutritional …

More awareness is needed in food service and culinary schools for the effect of the chefs’ smoking behavior on their salt use. Smoking is known to affect taste perception. Restaurant dishes are often high in salt and smoking might play a role in this. We show that prevalence of smoking among Dutch chefs …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Cardiovasculaire aandoeningen zijn wereldwijd de meest voorkomende doodsoorzaak en zorgen voor aanzienlijke zorgkosten. Het risico op deze aandoeningen neemt toe met de leeftijd, waarbij de oudere populatie aanzienlijk bijdraagt aan de totale zorgkosten. De AGE Reader mu, een innovatief apparaat dat …

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …