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Zocht je misschien: drugs, druk?

Expectations and Experiences of Participating in a Supervised and Home-Based Physical Exercise Intervention in Patients with Head and Neck Cancer during Chemoradiotherapy

Kok, Annemieke; Passchier, Ellen; May, Anne M; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Veenhof, Cindy; de Bree, Remco; Stuiver, Martijn M; Speksnijder, Caroline M

(1) Background: Chemoradiotherapy (CRT) for head and neck cancer (HNC) is associated with severe toxicity resulting in fatigue and weight loss, including loss of skeletal muscle mass. Exercise interventions might positively affect physical fitness and quality of life. Sufficient adherence and compliance …

2024-02-04AlgemeenArtikel

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Switching from a traditional undergraduate programme in (clinical) pharmacology and therapeutics to a problem-based learning programme

David J. Brinkman; Teresa Monteiro; Emilia C Monteiro; Milan C. Richir; Michiel A. van Agtmael; Jelle Tichelaar (Lector)

Abstract Purpose: The pharmacology and clinical pharmacology and therapeutics (CPT) education during the undergraduate medical curriculum of NOVA Medical School, Lisbon, Portugal, was changed from a traditional programme (i.e. discipline-based, lectures) to a problem-based learning (PBL) programme (i.e. …

2020-10-23GezondheidArtikel

Potential Clinical Consequences of Medication Process Problems in Older Home Care Patients

Nienke E Dijkstra (Lector); Carolien GM Sino (Lid Lectoraat); Marieke J Schuurmans (Lector); Marcel L Bouvy; Aline Bouwes (Docent); Eibert R Heerdink (Lector)

Background: Home care professionals regularly observe drug-related problems during home care provision. Problems related to the process of the medication therapy could involve discrepancies in medication prescriptions between the hospital discharge letter and the medication administration record lists …

2020GezondheidArtikel

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Heeres, André (Biobased Ingredients And Materials); Xu, Hu; van Marion, Denise MS; Hoogstra-Berends, Femke; Zhang, Deli; Seerden, Jean-Paul; Loen, Lizette; Steen, Herman; Henning, Robert H; Brundel, Bianca J J M

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character …

2019-01-18AlgemeenArtikel

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer

Anja Thronicke (Onderzoeker); Megan L. Steele (Onderzoeker); Christian Grah (Onderzoeker); Burkhard Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and …

2017-12-13GezondheidArtikel

Epidemiology and Outcome of Patients With Burns Treated With Cerium Nitrate Silversulfadiazine

Dutch Burn Repository group, Martini Hospital

In this study, the outcome of treatment with Flammacerium in burn patients is studied. The retrospective study involved patients with acute burns admitted to the Burn Centre of Martini Hospital, Groningen, The Netherlands, between 2009 and 2014. The outcome parameters were mortality, complications (noninfectious …

2017-01AlgemeenArtikel

Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients

Friedemann Schad (Onderzoeker); Anja Thronicke (Onderzoeker); Antje Merkle (Onderzoeker); Harald Matthes (Onderzoeker); Megan L. Steele (Onderzoeker)

Background: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been …

2017GezondheidArtikel

Antibiotic use in children with acute respiratory or ear infections

Harald J. Hamre (Onderzoeker); Anja Glockmann (Onderzoeker); Reinhard Schwarz (Onderzoeker); David S. Riley (Onderzoeker); Erik Baars (Lector); Helmut Kiene (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Children with acute respiratory or ear infections (RTI/OM) are often unnecessarily prescribed antibiotics. Antibiotic resistance is a major public health problem and antibiotic prescription for RTI/OM should be reduced. Anthroposophic treatment of RTI/OM includes anthroposophic medications, nonmedication …

2014-11-18GezondheidArtikel

Hydroximic acid derivatives

Crul, Tim; Toth, Noemi; Piotto, Stefano; Literati-Nagy, Peter; Tory, Kalman; Haldimann, Pierre; Kalmar, Bernadett; Greensmith, Linda; Torok, Zsolt; Balogh, Gabor; Gombos, Imre; Campana, Federica; Concilio, Simona; Gallyas, Ferenc; Nagy, Gabor; Berente, Zoltan; Gungor, Burcin; Peter, Maria; Glatz, Attila; Hunya, Akos; Literati-Nagy, Zsuzsanna; Vigh, Laszlo; Hoogstra-Berends, Femke; Heeres, André (Biobased Ingredients And Materials); Kuipers, Irma; Loen, Lizette; Seerden, Jean-Paul; Zhang, Deli; Meijering, Roelien A M; Henning, Robert H; Brundel, Bianca J J M; Kampinga, Harm H; Koranyi, Laszlo; Szilvassy, Zoltan; Mandl, Jozsef; Sumegi, Balazs; Febbraio, Mark A; Horvath, Ibolya; Hooper, Philip L; Vigh, Laszlo

According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

2013AlgemeenArtikel

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