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Recognition of cognitive dysfunction in hospitalised older patients

Fleur C. W. Visser; Marlise E. A. van Eersel; Liesbeth Hempenius; Nicolaas A. Verwey; Caterina Band; Robbert Gobbens (Lector); Barbara C. van Munster

Background: It is important that healthcare professionals recognise cognitive dysfunction in hospitalised older patients in order to address associated care needs, such as enhanced involvement of relatives and extra cognitive and functional support. However, studies analysing medical records suggest …

2024-01-16GezondheidArtikel

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Naaktgeboren, Willeke R.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker); Van Harten, Wim H.; Aaronson, Neil K.; Scott, Jessica M.; Sonke, Gabe; Van Der Wall, Elsken; Velthuis, Miranda; Leiner, Tim; Teske, Arco J.; May, Anne M.; Groen, Wim G.

Objective Animal data suggest that exercise during chemotherapy is cardioprotective, but clinical evidence to support this is limited. This study evaluated the effect of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity. Methods This is a follow-up study of two previously …

2023-10-30AlgemeenArtikel

A first exploration: can eye movement desensitization and reprocessing improve cognition in older adults with posttraumatic stress disorder?

E.M.J. Gielkens; G. Rossi; S.P.J. van Alphen; S. Sobczak

Objectives In older adults, PTSD is associated with decreased verbal learning and executive dysfunction. Therefore, feasibility of EMDR-treatment to improve cognitive performance in older adults with PTSD was examined. Additionally, we investigated pre-treatment correlation with often co-occurring risk …

2023-10-23GezondheidArtikel

Towards precision medicine for septic patients

Bram Snoek (Student)

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

2023-07-05Gezondheid; …Bachelor

Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Psychosocial factors associated with pain outcomes in patients with painful temporomandibular disorders and headaches

van der Meer, Hedwig A; Tol, Cornel H. M; Speksnijder, Caroline M; van Selms, Maurits K. A; Lobbezoo, Frank; Visscher, Corine M

The objective of this study was to assess the association between psychosocial factors (in terms of anxiety, somatization, depression, and optimism) and pain (in terms of headache pain intensity and pain-related disability), in patients with a painful temporomandibular disorder (TMD) and one of the following …

2023-04AlgemeenArtikel

A guide to identify cervical autonomic dysfunctions (and associated conditions) in patients with musculoskeletal disorders in physical therapy practice

Mourad, Firas; Giudice, Andrea; Maritati, Giorgio; Maselli, Filippo; Kranenburg, Rik (Healthy Ageing, Allied Health Care And Nursing); Taylor, Alan; Kerry, Roger; Hutting, Nathan

BACKGROUND: Differential diagnosis is a hot topic in physical therapy, especially for those working in a direct access setting dealing with neck pain and its associated disorders. All international guidelines agree in recommending to first rule out non-musculoskeletal pathologies as the cause of signs …

2023-03AlgemeenAndersoortig materiaal

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study

Roozeman, Jan-Paul; Mazzinari, Guido; Serpa Neto, Ary; Hollmann, Markus W.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.; Pisani, Luigi

BACKGROUND: The SpO2/FiO2 is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2 for mortality in patients with ARDS due to COVID-19. METHODS: This was a post-hoc analysis of a national multicenter cohort study in invasively …

2022-04AlgemeenArtikel

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