Hereditary Breast and Ovarian Cancer (HBOC) typically arises from mutations inherited in the germline. BRCA1 and BRCA2 mutaions are predominant contributors to HBOC, accounting for the majority of cases. These mutations are associated with 10% of ovarian cancer cases and 3-5% of breast cancer cases [4]. BRCA1 …

Recent studies showed that in teb mutants (teb2 & teb5 (mutant allele 2 and 5 of the Teb gene)) no T-DNA integration was detectable, meaning that if there still is any T-DNA integration it will be in very low frequencies (Kregten et al., 2016). This suggests that the Teb gene is essentially involved …

Using an optimized transformation protocol we have studied the possible interactions between transforming plasmid DNA and the Hansenula polymorpha genome. Plasmids consisting only of a pBR322 replicon, an antibiotic resistance marker for Escherichia coli and the Saccharomyces cerevisiae LEU2 gene were …